Milwaukee Brewers vs. New York Yankees: Picks, Predictions, Odds and Player Props

The New York Yankees were beaten by the Los Angeles Dodgers in the World Series last season and would dearly love to put the memories of that firmly behind them with a 28th title this year.

However, they have lost Juan Soto to the New York Mets and several more key players to injury, so it's worth watching to see how they fare in their season opener against the Milwaukee Brewers.

The Brew Crew topped the NL Central last year before losing to the Mets in the Wild Card Series, and beating the resurgent Chicago Cubs to the division title will be their priority with a similar squad to last season.  

Milwaukee Brewers vs. New York Yankees betting picks and predictions

Over 8.0 Total Runs (-110)

Gerrit Cole was supposed to be the New York Yankees Opening Day starter, but after suffering elbow discomfort following a spring training start, it was announced that the Cy Young winner would have Tommy John surgery and miss the entire 2025 season.

His absence means that Carlos Rodon has been given Opening Day honors for the Yankees ahead of free agent signing Max Fried. 

Left-hander Rodon produced an ERA of 3.96 last season and will face off against Freddy Peralta for the Milwaukee Brewers, who is coming off a rough spring training with an 8.56 ERA in just 13.2 innings pitched.

That said, Peralta has put up solid — if not exactly dominant — numbers over the years, with a 113 ERA+ since the start of 2022. 

One big move between these two teams in the offseason saw the Yankees acquire Brewers closer Devin Williams for starter Nestor Cortes, prospect Caleb Durbin and some cash.

Williams’ 39.4 strikeout rate is the fourth-best all-time and he will be a big miss in Milwaukee’s bullpen while providing the Yankees with a lights-out closer.

With some question marks around the pitching of both teams, it may pay to side with the Over.

Of New York’s 174 regular season and playoff games last season, 91 went hit the Over. They hit the most home runs in the league last year, 237, thanks in large part to AL MVP Aaron Judge, who continues to strike fear into pitchers’ hearts.

While they have lost Juan Soto, the additions of Cody Bellinger and Paul Goldschmidt will provide some pop to the lineup.

Milwaukee were also the sixth-highest scoring team in the majors last year, averaging 4.8 runs per game and their young star Jackson Chourio finished third in the NL Rookie of the Year voting and looks primed for a 30-30 campaign.

In what should be a competitive affair, Over 8.0 runs is the pick.

Rhys Hoskins home run (+425)

While all eyes will be on Aaron Judge to hit a home run in this season opener, Milwaukee's Rhys Hoskins could be a better option.

The Brewers slugger was red hot in spring training, hitting six home runs in just 51 plate appearances, and he has managed to hit at least 26 dingers in his last three full seasons.

He took Carlos Rodon deep last season and looks like a solid selection to have another home run in this game.

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Milwaukee Brewers vs. New York Yankees odds

Milwaukee Brewers	+125 ML
New York Yankees	-150 ML
Run Line	NY Yankees -1.5
Total	O/U 8.0

Milwaukee Brewers vs. New York Yankees player props

Player Home Run Odds

Aaron Judge (NY Yankees)	+200
Rhys Hoskins (MIL Brewers)	+425
Paul Goldschmidt (NY Yankees)	+475
William Contreras (MIL Brewers)	+475
Austin Wells (NY Yankees)	+525
Jazz Chisholm (NY Yankees)	+525

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.