Chicago Cubs vs. Philadelphia Phillies: Picks, Predictions, Odds and Player Props

The 2025 MLB season rolls on this week with a matchup between a couple of World Series hopefuls, as the Philadelphia Phillies are set to host the Chicago Cubs on Monday. 

Both of these teams are expected to be playoff-caliber sides, and this series could be a preview of a potential National League Division Series or Championship Series down the road. 

The Cubs have been one of the surprises of the season to this point, as Chicago holds one of the best records in baseball despite playing a difficult schedule and having to navigate through a number of injuries. 

On the other side, the Phillies are in the midst of their worst stretch of baseball of the season, having dropped nine of their last 10 games, including a sweep at the hands of the lowly Pittsburgh Pirates over the weekend. 

Will the Phillies bounce back and start this series with a victory, or will the Cubs keep rolling and get off on the right foot at Citizens Bank Park? Let’s get into the odds, plus our expert’s betting picks and predictions for this contest.   

Chicago Cubs vs. Philadelphia Phillies betting picks and predictions

Chicago Cubs ML (+110)

The Phillies have to be scratching their heads after getting swept by the Pirates, and things won’t get much easier for this struggling outfit as they will now have to face one of the best teams in the National League in the Chicago Cubs. 

Taking the mound for the Cubs will be the left-hander Matthew Boyd, who’s 5-3 with a 3.01 ERA on the season. Boyd pitched well in his last start against Washington, allowing just two earned runs in 7.1 innings pitched while striking out six in the process. 

Phillies ace Zack Wheeler will look to rebound from his last start, where he surrendered six runs over 5.1 innings pitched. Wheeler is 6-2 with a 2.96 ERA on the season, but our expert is concerned about the lack of run support he might get in this matchup. 

The biggest concern in potentially backing Philadelphia in this game is the way they are playing, especially at the plate, since they’re also going to be without Bryce Harper for an indefinite period of time. In June, they're second-to-last in MLB in OPS (.533) and tied for second-to-last in runs scored (18).

Ultimately, the Cubs are hitting the ball at a slightly better clip and Chicago also has a better bullpen. Chicago isn’t afraid to play on the road, posting a 20-14 record this season, which also gives our expert confidence.

Under 7.5 total runs (+100)

This pitching matchup is one that immediately points in the direction of the Under, especially since both lineups haven’t been great over the last week. 

Philadelphia is averaging just under 2.7 runs per game over its past six contests, while the Cubs are slightly better, averaging 3.7 runs in that span. 

Things won’t get any easier for either lineup against a pair of starting pitchers who have been rock solid all season long. In fact, both Wheeler and Boyd are due for a bit of positive regression heading into this outing, so we could certainly see each of them extend a little further than usual against a couple of struggling lineups.

Read more betting picks and predictions for MLB on site.

Chicago Cubs vs. Philadelphia Phillies odds

Chicago Cubs	+110 ML
Philadelphia Phillies	-130 ML
Run Line	PHI Phillies -1.5
Total	O/U 7.5

Chicago Cubs vs. Philadelphia Phillies player props

Player Home Run Odds

Kyle Schwarber (PHI Phillies)	+310
J.T. Realmuto (PHI Phillies)	+450
Trea Turner (PHI Phillies)	+500
Kyle Tucker (CHI Cubs)	+450
Seiya Suzuki (CHI Cubs)	+525
Pete Crow-Armstrong (CHI Cubs)	+525

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.