Chicago Cubs vs. New York Mets: Picks, Predictions, Odds and Player Props

The Chicago Cubs and New York Mets will continue their three-game series when they meet again at Citi Field in New York on Saturday night. A 7-2 victory in Friday’s opener improved the Mets’ record to 25-14 and extended their lead in the National League East to 2.5 games.

Although the Cubs have lost three in a row, they still lead the NL Central by two games.

With Saturday’s contest set for 7:15 pm ET on FOX, it’s time to break down the matchup and discuss the best bets to make.  

Chicago Cubs vs. New York Mets betting picks and predictions

New York Mets ML (-150)

With Juan Soto on board to join a lineup that already featured Pete Alonso and Francisco Lindor, the Mets are rolling along nicely in the early stages of the 2025 Major League Baseball season and find themselves 11 games over .500.

A recent 3-3 road trip was nothing special, but a return home should be just what the doctor ordered. After all, the Mets are 14-3 at Citi Field so far this season compared to 11-11 on the road.

Sure enough, New York opened this series with a dominant performance on Friday – complete with four home runs (including one each for Soto and Lindor) and 6.0 innings of one-run baseball from Clay Holmes.

The Cubs got solo homers from their usual suspects in Kyle Tucker and Michael Busch, but they could not muster up any additional offensive production. That has been their problem of late, as they have crossed the plate just eight times over their last three outings. Chicago also got shut out at Milwaukee this past Sunday.

Tonight’s pitching matchup should give the Mets an additional boost. Tylor Megill is toeing the rubber and he is 3-2 with a 2.50 ERA, 1.17 WHIP and 45 strikeouts in 36.0 innings of work. The Cubs are going with a bullpen day that will be opened by Brad Keller (0-0, 3.78 ERA).

New York should be in good shape both on the mound and at the plate, making the -150 money line a great play.

Over 8.5 (-120)

This is a matchup between two lethal lineups. Chicago is No. 1 in all of Major League Baseball with 225 runs scored, while New York leads the NL East with 188.

There is no reason to think that the Mets will slow down against a Cubs bullpen that owns the 10th-worst ERA in the league (4.63). Megill has been solid this year, but he has issued 15 walks and any failure to command the strike zone is going to be costly against these dangerous Cubs batters.

Three of Chicago’s last four games have produced at least nine runs; five of New York’s last seven have done the same.

Friday’s contest exceeded this 8.5 number and it would be no surprise if Saturday’s rematch does the same.

Juan Soto Over 1.5 hits + runs + RBIs (-135)

It took Soto a few weeks to find his footing with his new team, but he has caught fire of late. Five of the right fielder’s eight home runs have come in the month of May, including three in the last two games.

On Thursday and Friday he went a combined 4-for-8 with three dingers, five RBIs and three runs. He has scored nine runs in eight outings so far this month.

Now the Dominican left-hander faces a pitcher he has owned. Soto is 4-for-6 lifetime against Keller with two home runs and three walks. He won’t get more than one or two plate appearances with Keller on the mound tonight, but just one or two should be enough to send Soto on his way to another big day. 

Read more betting picks and predictions for the MLB on site.

Chicago Cubs vs. New York Mets odds

Chicago Cubs	+125 ML
New York Mets	-150 ML
Run Line	NY Mets -1.5
Total	O/U 8.5

Chicago Cubs vs. New York Mets player props

Player Home Run Odds

Kyle Tucker (CHI Cubs)	+390
Michael Busch (CHI Cubs)	+450
Seiya Suzuki (CHI Cubs)	+500
Pete Alonso (NY Mets)	+280
Juan Soto (NY Mets)	+350
Francisco Lindor (NY Mets)	+390

 Read the latest MLB news on site.

This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.