Skip to content
GO TO bet365 Sports
  1. MLB
  2. MLB Picks & Predictions

Arizona Diamondbacks vs. San Francisco Giants: Picks, Predictions, Odds and Player Props

It's a small slate with only five games happening around the country, but one that has gathered plenty of excitement is the last game of the night between the Arizona Diamondbacks and San Francisco Giants.

The Diamondbacks and Giants have both had less-than-ideal starts considering both teams come into this matchup with a losing record. 

The D-Backs have had a hard schedule up to this point as they’ve had to play the Yankees, Braves, Cardinals, and Cubs already.

It won’t get any easier with the Giants, who are starting Logan Webb. Webb is the ace of the staff and gives San Francisco its best chance of winning.

Arizona will oppose Webb with Ryne Nelson, a young righthander who is coming off his best start of the season. Let’s preview this divisional matchup and get into our expert’s best bets.

Arizona Diamondbacks vs. San Francisco Giants betting picks and predictions

Diamondbacks ML (+140)

Arizona’s strength has been their offense, which is led by Ketel Marte, Corbin Carroll, Christian Walker, and Lourdes Gurriel Jr. Plus, Eugenio Suarez has been a great addition to the lineup as he offers plenty of pop in the middle of the order.

Coming into this game, the Diamondbacks rank 5th in runs per game and 8th in batting average this season. That’s good news for Nelson, who is inconsistent on the mound and needs all the run support he can get. In his most recent start, he threw 6 innings and allowed just 1 run and 7 hits to the Cardinals.

Even with the signing of Blake Snell, the Giants' ace is Webb. Webb comes into this game with a 3.80 ERA and a 1.39 WHIP - both higher than his normal standards.

The ace appears to be a lot more hittable this season considering he’s surrendered 23 hits in just 17.2 innings, and that’s a bad trend against a Diamondbacks offense that has plenty of contact hitters from the leadoff spot to the nine-hole hitter.

Plus, San Francisco’s bullpen has been unreliable in the first three weeks. At such good odds, the Diamondbacks are worth the play as underdogs.

Under 8.0 (-115)

Offense has been the biggest weakness for the Giants this season. Even with offseason acquisitions Jorge Soler, Jung Hoo Lee, and Matt Chapman, the lineup has not been as productive as many expected.

The Giants scored just 10 runs in their most recent series against the Marlins which has them currently placed at 19th in runs per game.

Once the lineup starts to improve, the Giants will be dangerous because of their excellent pitching. However, that time still seems far away.

Webb and Nelson couldn’t be more different in regards to their style of pitching. Webb primarily uses a changeup and sinker to keep the ball on the ground which is why his career ground ball rate is nearly 60% - roughly 15% higher than the MLB average.

But Nelson primarily throws a fastball and a cutter and that results in plenty of fly balls - nearly 10% higher than the MLB average.

That should work well in San Francisco since it’s a pitchers park and not easy to hit home runs in. Between two strong pitchers and a weak Giants lineup, take the under in the series opener.

Read more betting picks and predictions for the MLB on site

Arizona Diamondbacks vs. San Francisco Giants odds

Arizona Diamondbacks


San Francisco Giants


Run Line

Giants -1.5 (+130)


Over 8 (-105), Under 8 (-115)

Arizona Diamondbacks vs. San Francisco Giants player props

Player Home Run Odds

Ketel Marte (ARI)


Corbin Carroll (ARI)


Lourdes Gurriel Jr (ARI)


Jorge Soler (SF)


Jung Hoo Lee (SF)


Matt Chapman (SF)


Read Arizona Diamondbacks vs. San Francisco Giants: How to watch, TV Channel, streaming, start time, starting pitchers, injury report and stats on site

Read the latest MLB news on site

This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.

Related Articles

bet365 uses cookies

We use cookies to deliver a better and more personalized service. For more information, see our Cookie Policy

New to bet365? Bet $1 & Get $365 in Bonus Bets Join Now

Deposit required. Bonus Bet winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs, time limits and exclusions apply.