The Los Angeles Rams and New York Giants meet in a primetime spot that feels like a classic bounce‑back setup for Los Angeles on Monday night at SoFi Stadium.
Sean McVay’s men have had 11 full days to reset after a disappointing day Down Under as their decision to take a whistlestop trip to Melbourne backfired in a 27-7 defeat to the San Francisco 49ers.
The Rams are priced as strong favorites to overcome a Giants team that upset the odds at home to the Dallas Cowboys last Sunday.
New York Giants vs. Los Angeles Rams betting tips and predictions
Los Angeles Rams -6.5 (-120)
The Rams looked very flat in Australia and now we will get to find out if that was because of jet-lag or whether some deeper issues need resolving.
Los Angeles recorded no sacks, scored only seven points, and their fearsome passing attack never found any timing against the Niners.
But the return of Aaron Donald this week changes the complexion of their defense entirely.
The three-time Defensive Player of the Year and eight-time First Team All-Pro is finally good to go after shaking off the rust of a two-year retirement hiatus.
And his experience could be key in a matchup against rookie guard Sisi Mauigoa, who impressed on his NFL debut last week.
Many of the Giants shone against Dallas as QB Jaxson Dart completed 23 of 29 passes for 230 yards and three touchdowns, while RB Cam Skattebo scampered for 81 rushing yards.
However, sustaining that level on the road against a rested, angry Rams team is a different story.
New York’s offensive line is also banged up, with LT Andrew Thomas and RG Francis Mauigoa on the injury report alongside DT Chauncey Golston, ILB Micah McFadden, and cornerbacks Greg Newsome and Deonte Banks.
Los Angeles will be without pass-rushing stud Myles Garrett in this contest, and could also be without Puka Nacua, who is doubtful with a hip injury.
But they have far superior offensive weapons than the Giants and their defense should be much tougher to breach with Donald at its heart.
Rams to win Race to 30 Points (+115)
The Rams scored a league-high 518 points in the 2025 regular season and will be disappointed to have only put seven on the board in Melbourne.
Los Angeles were down by a field goal heading into the second half, and put themselves in a good position to keep the 49ers within range when they answered a San Francisco score with a strong drive of their own, before they were stopped at the one-yard line.
The Rams defense then gave up a 99-yard touchdown drive and suddenly found themselves down 17 points.
Had their offense punched it in from the one, it would still have been a three-point game, but they instead trailed by three scores.
That made their task so much harder, so it will be crucial for them to finish off their drives on Sunday against a Giants team with rising belief.
The Rams’ offensive ceiling is simply higher than New York’s, even with Nacua a doubt to suit up through injury.
Matthew Stafford and Davonte Adams can overwhelm a Giants injury-hit secondary but Donald’s return is the biggest swing factor here.
He has not played since January 2024, but his presence alone shifts protection schemes, creates pressure lanes, and shortens drives. New York’s margin for error shrinks dramatically when Donald is on the field.
The Rams won the race to 30 points in five of their final seven regular-season games in 2025 while the Giants have not reached that total in 13 of their last 18 outings.
Kyren Williams first touchdown scorer (+320)
Williams was the lone bright spot in Los Angeles’ opener, scoring their only touchdown and continuing the form he showed last postseason.
He has now scored in four straight games, including all three playoff contests last year.
The Giants allowed both a rushing and receiving touchdown to Javonte Williams in Week 1, and their front seven struggled to contain Dallas’ interior run game.
With Donald returning — improving field position and shortening drives — Williams should see multiple red‑zone touches.
He is the most likely Ram to score first, especially if Nacua sits and Los Angeles leans on balance early.
Read more betting picks and predictions for the NFL on site.
New York Giants vs. Los Angeles Rams odds
New York Giants | +255 |
Los Angeles Rams | -315 |
Spread | LA Rams -6.5 |
Total | O/U 47.5 |
New York Giants vs. Los Angeles Rams player props
Anytime touchdown
Kyren Williams (LA Rams) | -170 |
Puka Nacua (LA Rams) | +100 |
Davante Adams (LA Rams) | +105 |
Cam Skattebo (NY Giants) | +125 |
Blake Corum (LA Rams) | +185 |
Malik Nabers (NY Giants) | +200 |
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
