Thursday Night Football in Week 3 has what could be one of the most one-sided affairs of the week, as the San Francisco 49ers host the New York Giants.

The 49ers are justifying their pre-season billing as potential NFL Championship title contenders after back-to-back wins going into Week 3.

Meanwhile, the Giants find themselves 1-1 going into this trip to Levi’s Stadium, but it’s their defensive shortcomings that will be most worrying for fans going into this California road game.

What	New York Giants @ San Francisco 49ers
Where	Levi’s Stadium, San Francisco, California
When	8:15 PM ET, Thursday, September 21
How to watch	Amazon Prime
Odds	49ers -10.5, Giants +450 ML

Purdy starting nicely

With Jimmy Garoppolo making the move to the Las Vegas Raiders, there were plenty of questions about Brock Purdy’s ability to step up and become the main man for the 49ers this season.

Early signs are looking good for the quarterback, with San Francisco’s offense putting up 60 points through the first two weeks of the season.

The 49ers offence got the job done with a 30-7 victory over Pittsburgh Steelers in Week 1, before another impressive attacking display to beat the Los Angeles Rams 30-23.

Wide receiver Brandon Aiyuk has benefitted from Purdy’s strong start to the season with two touchdowns in 11 receptions for the 49ers.

Aiyuk is available at +137 to score a touchdown anytime against the Giants and he is +750 to score the first of the game.

Running back Christian McCaffrey has also enjoyed a strong start to the season with two touchdowns in his first two appearances of the campaign.

The former Carolina Panthers star, who made the switch to the 49ers last year, is +225 to score the first touchdown against the Giants.

This is an offense that seems to be growing in confidence and one that will be raring to get stuck into a Giants’ defense that has been found wanting at the start of the season.

Giants’ defense leaves plenty to be desired

Giants fans headed into their team’s opening game against the Dallas Cowboys at MetLife Stadium with hope more than expectation.

Few would have imagined leaving the stadium with their side losing 40-0 to an NFC East rival.

Two interceptions thrown by quarterback Daniel Jones certainly did not help the hosts' cause as the Cowboys were 26-0 up at half-time.

Credit to the Giants though, after a tough week with plenty of soul searching, New York responded with a 31-28 win on the road at the Arizona Cardinals.

The Giants even gave the Cardinals a 20-point head start before mounting a comeback in the third and fourth quarters.

Basic errors have been costing the Giants points in the first two weeks of the season and next they face their toughest test of the campaign so far in San Francisco.

A one-sided affair in store?

New York certainly won’t be able to afford the 49ers the luxury of a head start if they are to head back to the East Coast with the W this week.

The 49ers offense will be relishing the prospect of getting at a Giants’ defence that may well be in for a long evening at Levi’s Stadium.

Looking at the Spread, the 49ers are favored by -10.5 points for Thursday’s clash.

It certainly looks set to be a big test for Giants’ head coach Brian Daboll. He has a challenge on his hands to keep New York from falling away in the NFC East, with rivals Dallas, Philadelphia Eagles and Washington Commanders all looking to challenge for the divisional crown this season.

The NFC East winner odds reflect that at this early stage of the campaign, with the Giants available at +2000 to finish top of the pile at the end of the regular season.

At the other end of the spectrum, the 49ers are +650 joint-favorites to win the NFL Championship.