Two NFC West foes, the Los Angeles Rams and San Francisco 49ers, travel halfway across the world to Melbourne, Australia in the second game of the new 2026 NFL season.
The first game of the year between the New England Patriots and Seattle Seahawks brought an intense finish that saw Drake Maye throw three interceptions in the fourth quarter to seal the win for Seattle in the Super Bowl rematch.
Tonight, we get to see superstars Myles Garrett, Matthew Stafford, and Puka Nacua take on the likes of Christian McCaffrey, Brock Purdy, Nick Bosa, and Fred Warner.
The Elias Sports Bureau, a sports-statistics based data company has partnered with bet365 for this NFL season to provide unique, stat-backed markets.
These markets are available for every week throughout the NFL season, and they have plenty of offerings for tonight's game. You can check them out on the bet365 sportsbook.
Below is a list of all the stat-based markets provided by Elias. Be sure to also check out our partner authors' expert betting picks and predictions for 49ers vs. Rams on site.
San Francisco 49ers vs. Los Angeles Rams: Elias Insights Betting Specials
Adams 7+ Receptions & 1+ Receiving TD (+825)
Last year, Davante Adams caught 14 touchdown passes despite having zero games with more than six receptions. The NFL has not seen a season like that since Warren Wells in 1969. Will Adams leave 2025 in the past and start this new campaign with a 7+ catch performance?
Both Evans & Stribling 5+ Receptions & 50+ Receiving Yards (+1400)
This game will likely feature two playmakers making their debut for the 49ers: 13-year veteran Mike Evans and highly-touted rookie De'Zhaun Stribling. These two are aiming to be the first pair of 49ers to tally 5+ catches and 50+ yards in the same debut game. This was most recently done by rookies Dylan Sampson and Harold Fannin Jr. of the Cleveland Browns last season.
McCaffrey 8+ Receptions & 65+ Receiving Yards (+1200)
Christian McCaffrey comes into this matchup looking to record his third straight game against the Rams with 8+ catches and 65+ receiving yards. A running back has only ever done this in three straight games against a specific opponent once: McCaffrey himself, against the Falcons between 2018 and 2019 (four straight games).
Stafford 1+ Pass TD to a TE (-200)
Matthew Stafford connected with a tight end for a touchdown a league-high 17 times last season. Over the last 10 years, just two other QBs threw as many touchdowns to TEs in a single season: Andrew Luck (21 in 2018) and Lamar Jackson (18 in 2024). Can Stafford and co. pick right back up where they left off?
Stafford 280+ Pass Yards & 3+ Pass TD (+425)
Matthew Stafford had 389 yards and 3 TD and then 280 yards and 4 TD in each of his last two meetings with the 49ers. Should he continue this hot streak, he'll be the third ever QB with 280+ yards and 3+ passing TD in three consecutive games against the 49ers, joining Steve Beuerlein (1999-2000) and Drew Brees (2014-2019).
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