Week 4 of the college football season looked like one of the best slates we've had in the last decade and it certainly lived up to the billing. What will Week 5 do for an encore?

Well, we’ve got plenty of games on the schedule for college football fans and bettors alike, including Notre Dame vs Duke, LSU vs Ole Miss, Kansas vs Texas and more.

It’s time to take a look at the biggest games on the schedule for Week 5 of the college football season.

No. 11 Notre Dame Fighting Irish vs. No. 17 Duke Blue Devils

This could very well be the biggest game in the history of the Duke football program, as College GameDay is on campus and the Blue Devils have the primetime slot on ABC to host a reeling Notre Dame team.

The teams have produced similarly so far this season: Duke scores 37.3 points per game while Notre Dame averages 39.6, and Duke allows 8.8 points per game to Notre Dame's 12.8.

Can the Fighting Irish rebound from an absolutely demoralizing loss in the final seconds against Ohio State last week, or will Duke seize the moment and pull off the upset?

Depite the possibility their confidence took a hit in Week 4, Notre Dame is favored by -5.5. Duke is +180 ML.

No. 13 LSU Tigers vs. No. 20 Ole Miss Rebels

In another matchup between ranked teams, this game between LSU and Ole Miss will likely go a long way into deciding who eventually wins the SEC West division.

Both teams are coming off underwhelming performances, but the key to this game will be LSU’s weak secondary against Jaxson Dart and the Ole Miss passing attack, which was stymied by Alabama a week ago.

Jaylen Daniels and this Tigers offense is firing on all cylinders of late. But this Rebels defense has been sneaky good this season, including against the Crimson Tide, holding teams to 18.5 points per game while scoring 42 on average.

LSU is favored by -2.5 in the 6 PM ET game, while Ole Miss is +120 ML.

No. 10 Utah Utes vs. No. 19 Oregon State Beavers

The PAC-12 is going to be a war all season long and no game epitomizes the gauntlet that this conference is on a week-to-week basis more than this contest between the Utah Utes and Oregon State Beavers on Friday at 9 PM ET.

The Utes have rode their stout defense to a 4-0 start, even as the offense has struggled without the services of Cam Rising at quarterback.

On the other side, Oregon State is coming off a tough loss against Washington State, but a home game in prime time presents a great opportunity for a bounce-back effort on Friday.

Assuming Rising can’t go in Friday’s contest as he rehabs a knee injury, it’s hard not to lean toward a defensive struggle from a pair of teams that will look to run the ball and limit explosive plays from the opponent.

Oregon State, led by former Clemson Tigers QB DJ Uiagaleilei, is favored by -3.5 while Utah is +145 ML.

No. 24 Kansas Jayhawks vs. No. 3 Texas Longhorns

Two seasons ago, the Kansas Jayhawks went to Austin and knocked off the Texas Longhorns as nearly 4 touchdown underdogs in what was one of the most memorable games of the 2021 season.

Don’t think Steve Sarkisian has forgotten about that game and he’ll undoubtedly have his team ready for what should be a highly anticipated matchup for the Longhorns and their fans.

The Kansas offense is absolutely elite under coach Lance Leipold, but this is by far the best defense the Jayhawks have faced to date.

bet365 News Team

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