This year's NFL Championship will see two brothers on opposite sides for the first time when Travis Kelce's Kansas City Chiefs face Jason's Philadelphia Eagles.
The McCourty twins, Devin and Jason, both started in the secondary for the New England Patriots in their 13-3 defeat of the Los Angeles Rams in the climax to the 2018 season.
And of course, the Harbaugh brothers were the head coaches of rival teams on Championship Sunday ten years ago, but this is the first time any player's family will have split loyalties.
To mark this moment in history, let's examine some of the best current brother duos in the NFL.
Born two years apart, the Kelce brothers grew up in Cleveland Heights, Ohio and supported the Browns.
They followed different paths to the NFL with Jason playing ice hockey in high school and Travis focussing on basketball, but both later attended the University of Cincinnati and played football.
A starting left guard and center for the Bearcats, Jason's college performances caught the eye of the Philadelphia Eagles and they made him their fourth-round selection in the 2011 draft after he had produced a scorching 4.89-second 40-yard dash at the Scouting Combine.
He made such an impression on then-Eagles head coach Andy Reid that he became the first rookie in franchise history to start all 16 games at center and later went on to win his first NFL Championship ring at the end of the 2017 season.
Two years later it was his sibling's turn to take the spotlight with a stellar performance for Reid's Kansas City Chiefs in their 31-20 NFL Championship win over the San Francisco 49ers.
The two brothers have faced off only twice in their careers, in 2017 and 2021, with the Chiefs victorious on both occasions.
Travis, who is +650 to score the first touchdown a week on Sunday, starred with over 100 yards receiving and a TD in the first encounter.
While the Kelces are gearing up for the big game, the Diggs brothers are having fun in Las Vegas at the Pro Bowl.
Stefon is the older of the duo by five years and helped his mother take care of her children after their father passed away in 2008.
Both are now stars of the sport with Stefon a former NFL receptions and receiving yards leader in 2020 and Trevon having led the NFL in interceptions a year ago.
The two brothers have not played against each other at the NFL level yet with Stefon's switch of conference from the Minnesota Vikings to the Buffalo Bills coming just before Trevon was drafted by the Dallas Cowboys.
But there was some interesting trash talk exchanged between the pair last summer when the Cowboys cornerback said his brother would not catch one pass against him if they lined up on opposite sides in an NFL Championship game.
Stefon left Josh Allen to counter the claim on his behalf by predicting that his wide receiver would register ten catches for 160 yards and two TDs.
The New York Jets' band of brothers hail from Alabama and were both selected in the 2020 draft, albeit in differing circumstances.
The Jets used their No.3 overall selection to snag Quinnen to play on the interior of their defensive line while linebacker Quincy was taken 95 picks later by the Jacksonville Jaguars.
They were reunited in September 2021 when the Jets picked Quincy up off the waiver wire and they have not regretted the move with Quinnen's older brother now an established starter and recognized as one of the hardest hitters in the NFL.
Both coming through the Catholic Youth Organization's football program in Indiana, Zack and younger brother Nick were destined to play college football for Notre Dame and make it as NFL prospects.
Zack landed with the Cowboys as a first-round pick in 2014 and has since been to the Pro Bowl eight times, earning All-Pro honors for a sixth time in 2022.
Nick spent four years with the Houston Texans before spells with the Las Vegas Raiders and New Orleans Saints.
He was signed by the Washington Commanders in the early part of the 2022 season and started in the Week 4 NFC East rivalry clash with the Cowboys.
The sons of former Miami Dolphins defensive end John Bosa, Joey and Nick both made immediate impacts upon their arrivals in the NFL - winning Defensive Rookie of the Year three years apart.
Joey bettered his 10.5 sack rookie total by recording a career-best 12.5 sacks for the Los Angeles Chargers in 2017.
But little brother Nick is swiftly catching up to his 60.5 sack total after a slower start, moving on to 43.0 through his first four years in the league after racking up an incredible 18.5 for the Sa Francisco 49ers this year.