The 32 NFL teams have been busy integrating new talent acquired via the draft or free agency and now the first of the 272 regular-season games isn't far away.
A spring frenzy of blockbuster trades has given way to a summer of hard work for the coaches as they put players battling for places on the 53-man roster - the maximum number teams can keep during the regular season - through their paces.
A star-studded Los Angeles Rams team that included Aaron Donald, Jalen Ramsey, Odell Beckham Jr, Cooper Kupp and Von Miller took possession of the Vince Lombardi Trophy after last season's 20-17 win over the Cincinnati Bengals in Super Bowl LVI.
Miller is now in Buffalo and his new team - the Bills - are not only rated as this year's 13/2 favourites to win it all, but they also get first shot at the champions in the Kickoff Game on 9th September.
What: NFL Season 2022/23
Where: All across the U.S.A with three games scheduled for London, one for Munich and one in Mexico City
When: 01:20, Thursday 9th September 2022
How to watch: The vast majority of games are live and on-demand with NFL Game Pass, while selected games are available via Sky Sports and Sports Live Streaming platform
Odds: BUF Bills 13/2, TB Buccaneers 7/1, KC Chiefs 10/1, LA Rams 10/1, GB Packers 10/1
The 2022 season is scheduled to begin with the Kickoff Game between Buffalo Bills and Los Angeles Rams on Thursday 9th September at 01:20 and runs through to Super Bowl Sunday on 12th February 2023 with the majority of regular-season and playoff games taking place on Sundays.
A total of 267 regular-season games will be played across the United States with five more hosted overseas in Europe and Mexico. Three games are slated for London - two at Tottenham Hotspur Stadium and one at Wembley - plus the NFL makes its German debut in Munich and heads back to Mexico City's Azteca Stadium for the first time since 2019.
Among the most iconic NFL venues to host games this year will be Lambeau Field, Green Bay and Allegiant Stadium, Las Vegas.
Any American football nut wanting access to the most comprehensive coverage will need the NFL's own Game Pass, to which Blackout restrictions apply in the UK during the regular season. Selected games will be available to viewers able to access Sky Sports and, as in 2021, Sports Live Streaming platform.
The 2022 NFL season is scheduled to be the 103rd season of the National Football League, but the first Super Bowl didn't take place until after the NFL-AFL merger of 1966. That was when the Green Bay Packers, coached by the legendary Lombardi whose name now adorns the ultimate prize, defeated the Kansas City Chiefs at the Los Angeles Memorial Coliseum.
There have been 56 Super Bowls to date with the Los Angeles Rams victorious at their own SoFi Stadium against the Cincinnati Bengals in Super Bowl LVI last February.
The Packers have won the most championships with 13 in total, including four Super Bowls. The most successful teams of the modern era are the Pittsburgh Steelers and New England Patriots with six Super Bowls apiece, closely followed by the San Francisco 49ers and Dallas Cowboys on five each.
Last January, the aforementioned Bills came agonisingly close to eliminating the back-to-back AFC champion Chiefs in an Arrowhead Stadium shootout that will live long in the memory. In an epic finale to regulation, Bills quarterback Josh Allen tossed a 27-yard score to Gabriel Davis on a do-or-die fourth-and-13 that put Buffalo three points ahead with less than two minutes remaining.
Chiefs star Patrick Mahomes then connected with receiver Tyreek Hill on 64-yard touchdown pass to complete a five-play, 75-yard drive in 52 seconds only for Allen and the Bills to strike again - this time only leaving the hosts 13 seconds to make up the three-point gap.
That they did with two quick passes from scrimmage and a clutch field goal completion and the rivals were headed for overtime. What happened next left a bitter taste in Bills fans' - and many neutrals' - mouths as Kansas City called correctly at the coin toss and Mahomes won the game with an inch-perfect back shoulder pass to tight end Travis Kelce in the end zone, denying Buffalo a chance to respond.
The Super Bowl favourites will be all out for revenge this year and looking to secure home field advantage for any possible grudge match in the playoffs.