2025 NBA Playoffs: Indiana Pacers vs. Cleveland Cavaliers second-round series odds

The Indiana Pacers, who entered the second-round series against the Cleveland Cavaliers as underdogs, now have a 3-1 lead over the Eastern Conference's No. 1 seed.

The Pacers benefited from injuries to Cavs stars Darius Garland, Evan Mobley, and De'Andre Hunter early in the series. Cleveland won the first game with those three players healthy in Game 3, but that shouldn't detract from Tyrese Haliburton and company's heroics.

Indy won Game 1 by nine points before a heroic Game 2 comeback. The Pacers were down seven points with less than a minute left, but they forced two turnovers and scored on three straight possessions — capped off by a Haliburton game-winning step-back three-pointer — to seal the one-point win and take a 2-0 series lead.

Cleveland got back in the win column with a 22-point win in Game 3 on the back of a 43-point game from Donovan Mitchell. But, the Pacers dominated Game 4, winning 129-109 after leading by 44 early in the third quarter. Indy shot 10 percent better than the Cavs and committed 12 fewer turnovers.

Will the Cavs stage a successful comeback from a 3-1 deficit for just the 13th time in NBA history?

With Indiana holding a 3-1 lead after Game 4, let's take a look at the updated odds.

Indiana Pacers vs. Cleveland Cavaliers second-round series odds

Pacers lead series 3-1

To Win Series - After Game 4

IND Pacers	-310
CLE Cavaliers	+250

Prior to the series, the Cavaliers were -500 favorites and the Pacers were +375 underdogs.

Series Correct Score - After Game 4

Series Score	Pacers to win	Cavaliers to win
4-1	+220	-
4-2	+190	-
4-3	+600	+250

Prior to the series, Cavaliers to win 4-1 had the shortest odds of any outcome at +230.

When Series Will Finish - After Game 4

Game 5	+220
Game 6	+190
Game 7	+135

Prior to the series, Game 5 had the shortest odds (+200) to be the final game in the series.

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Odds displayed within this article were correct at the time of writing and are subject to change.