Chelsea's draw with West Ham meant their winless run away from home extended to seven games as their slide down the table continued.
Any faint hopes of a top four finish (12/1) grow dimmer by the week, and even a top six finish (7/4) is no certainty.
That run of five straight wins and four straight clean sheets shortly after Graham Potter's arrival at Stamford Bridge feels a very distant memory, and he'll be desperate for his Chelsea side to show signs of improvement quickly.
In League One, a resurgent Bolton have strengthened their play-off credentials and are 1/6 to finish in the top six and 5/2 to be promoted on the back of four consecutive wins.
It took the Trotters a few weeks to find their feet, picking up eight points from their first six games, but Ian Evatt's side have largely stayed in the play-off places, despite a run of five wins in 15 games, and look a safe bet to still be there come May.
In La Liga, a rampant Barcelona continue their march towards the title with a sixth straight win and are now as short as 1/12 to win the league. Their incredible rear-guard has seen them concede just seven goals in 21 games, while early pace-setters Real Madrid - who beat Barcelona 3-1 in October - dropped points for the fifth time in nine matches.