There are some key contests in Italy, Germany, France and Spain this Saturday with a handful of sides putting their European qualification credentials on the line.
Roma will be without their boss in the dugout for the key visit of Atalanta, while Real Madrid can take a major step towards La Liga glory if they overcome Real Sociedad, with all the action included in our European Soccer Live Streaming Highlights.
Jose Mourinho never strays far from controversy and has been in the headlines again recently for his gestures towards a match official in Roma's 2-2 draw with Verona last month.
The club have since decided to not appeal against the decision, meaning the Portuguese boss will continue to serve his two-match touchline ban against Atalanta this Saturday.
Unfortunately for the capital club this is a huge contest to be without their manager on the sidelines but they should still fancy their chances of causing an upset.
Roma are 31/20 to overcome Atalanta, who are 17/10 to prevail with the draw 12/5 in Italy's top flight.
Mourinho's side go into this match on a six-game unbeaten run in the league, so they should at least feel confident of avoiding defeat.
They have lost only three times at their Stadio Olimpico home in Serie A this term and do not have a lengthy injury list.
Leonardo Spinazzola, Sergio Oliveira and Felix Afena-Gyan are their only absentees, whereas Atalanta are hindered in the final third by the ongoing absences of top scorer Duvan Zapata and creative influence Josip Ilicic.
As a result, the Bergamo side have managed only one win in their last six league contests and, despite Mourinho's absence this weekend, they could be more vulnerable on Rome soil than expected.
Victory for Roma would move them level on points with Atalanta in the Serie A standings and they have every chance of pulling off a key victory.
Bayern Munich are well on course for a tenth successive Bundesliga title but Julian Nagelsmann's side have shown signs of vulnerability of late and Bayer Leverkusen will be looking to capitalise.
The Bavarians edged past Eintracht Frankfurt last time out but were beaten by Bochum and held to a draw by Salzburg in February.
And although they have an eight-point advantage over Borussia Dortmund heading into Saturday's contest with Bayer Leverkusen, they will still be looking over their shoulders slightly.
Leverkusen should not be underestimated. Their all-or-nothing approach this season has seen their matches feature an average of 4.25 goals per game - the highest in the division.
Patrik Schick, who has 20 league goals, is a potential doubt but they are still in possession of top talents Moussa Diaby and Florian Wirtz, who have 19 goals and 17 assists between them in Germany's top flight this term.
And punters can expect them to operate on the front foot against a Bayern team who are dealing with a host of absences.
Alphonso Davies, Corentin Tolisso, Thomas Muller, Manuel Neuer, Leon Goretzka and Lucas Hernandez, who is suspended, are all expected to miss this clash and that could tilt the match in Leverkusen's favour.
They won 5-2 away to Borussia Dortmund only last month and are another side who should not be underestimated this Saturday - they are 6/1 to pull off a shock win against Munich, who are 2/5 with the draw 9/2.
With a 2-0 win over Versailles, Nice booked their place in the final of the Coupe de France on Tuesday but they will not face Nantes in the final until May and must quickly turn their attention back to Ligue 1.
On current form, they risk tumbling out of the race for the top three in France's elite division and this is not a good time for them to meet champions-elect PSG, who have won 19 of their 26 matches so far.
Nice have managed only one win in their last four league games, beating Angers but losing to Clermont Foot and Lyon and drawing with Strasbourg.
In their last league game they saw both defender Dante and forward Justin Kluivert sent off and the pair are set to miss Saturday's game with the Parisiens.
PSG, meanwhile, have won four of their previous five matches, defeating Lille, Rennes, Real Madrid and St-Etienne as part of that run and they have looked imperious of late.
PSG, meanwhile, are 3/4 to win and that looks a good price given the contrasting form of the two teams right now. Nice are 16/5 to win at their Allianz Riviera home while the stalemate can be backed at 3/1.
Sevilla may have taken the spoils in their Andalusian derby with Real Betis last time out but it is still Real Madrid who sit top of the pile in La Liga with a six-point buffer.
And although at first glance Real Sociedad may be considered a potential banana skin this Saturday, Los Blancos should justify their 8/13 price at the Santiago Bernabeu.
David Alaba and Eder Militao have been a rock solid defensive partnership this season with the team shipping only 20 goals in 26 La Liga assignments and their opponents Real Sociedad have had a tough time of it recently.
The Basque side were thumped 4-0 by rivals Athletic Bilbao last month and were also dumped out of the Europa League by Leipzig.
They are 15/4 to get the better of Real Madrid with the draw 10/3 but it is hard to look beyond a home win in the Spanish capital.