Plymouth, Ipswich and Sheffield Wednesday, the runaway top three in League One, will be determined to get back to winning ways on Saturday after each of them dropped points last weekend.
Elsewhere, it's crisis time at The Valley following the sacking of Ben Garner and dismal FA Cup exit at Stockport, piling the pressure on the Addicks' players as they head to bottom club Morecambe.
The wheels have hardly come off the tractor, but Ipswich could definitely do with getting their foot down again, and beating Peterborough would be a move in the right direction.
Town have been in front in each of their last four league games yet won only one of them, drawing the other three.
The sides have met 10 times in league football and Ipswich have won only one of those, though the formbook suggests No.2 occurs on Saturday.
A win or a draw will send Ipswich back to the top of the table for a few hours, and longer if Plymouth lose at Cambridge later on in the afternoon.
Argyle's surprising 2-0 home loss against Port Vale last time out was their first league defeat since August, though their fans and backers would expect them to deliver at at Cambridge, who are without a win in four in the league.
It's one league win in two-and-a-half months for Portsmouth who are in danger of slipping out of the promotion race.
They are still 3/1 to be promoted but there would be few takers based on Sunday's 2-0 loss at Wycombe, by some distance their worst performance of the season.
They are unbeaten at Fratton Park but need to start picking up wins on the road, starting at lowly Accrington, who have not beaten a top-half team yet this season.
That said, Stanley's last five games have produced just six goals so they are proving tough to break down and tough to beat.
Just three League One bosses have departed since the start of term, the third of those this week when Ben Garner's reign at Charlton came to an end.
The final straw was last Friday's 1-0 home defeat by Cheltenham which left the Addicks winless in five and as close to the bottom four as the top six.
Anthony Hayes was promoted from the youth team to take caretaker charge at Stockport in an FA Cup second round replay on Wednesday and that also ended badly, the League Two team winning 3-1.
They will be desperate for a win at bottom club Morecambe, though the Shrimpers are no pushovers as they fight for survival.
The League One card features two intriguing derbies with neighbours Burton Albion and Derby meeting at a sold-out Pirelli Stadium, just the fifth competitive showdown between the clubs.
Paul Warne's Rams are fancied at 13/10 though the draw at looks a serious contender.
Derby are unbeaten in ten in all competitions but six of those have been draws, while Burton might be struggling in the bottom four but they are unbeaten in their last six, with stalemates in four of their last five.
Down in the south-west, meanwhile, it's time for El Glosico, the all-Gloucestershire square-up between Forest Green and Cheltenham, two of the division's lowest scorers.