Dubbed Der Klassiker, Borussia Dortmund v Bayern Munich has become the biggest game in German football.
It is not a rivalry stemming from geography, religion or social differences like some of the other big derbies in the world but rather the result of the success of the two teams in the German Bundesliga with Dortmund and Bayern having won 23 of the last 27 top-flight titles between them.
Here is all you need to know about Der Klassiker, which has served up some memorable moments in years gone by.
As of April 2022, Borussia Dortmund and Bayern Munich have played one another 126 times in league and cup competitions, having locked horns for the first time in the 1965/66 season with Dortmund winning the first meeting 2-0.
Bayern Munich have been the more successful team in Der Klassiker, winning 61 of their 126 meetings with Borussia Dortmund.
Dortmund have endured more defeats (52) and conceded more goals (213) in the Bundesliga against Bayern than against any other team.
On the way to only their second ever Bundesliga title, Bayern Munich thumped Borussia Dortmund 11-1 at the Grünwalder Stadion in November 1971.
That contributed to a tally of 101 goals for champions Bayern that season, whilst Dortmund finished 17th in the standings and were relegated.
It is fair to say that Der Klassiker has been at its best in the last decade or so and the key to the more recent success of both sides was Polish superstar Robert Lewandowski.
Lewandowski arrived at Dortmund as a relatively unknown talent in 2010 and went on to win back-to-back Bundesliga titles with Die Schwarzgelben under the guidance of Jurgen Klopp.
Scoring 103 goals in 187 appearances for Dortmund, Lewandowski also helped the club win the DFB Pokal in the 2011/12 season and spearheaded their attack in the final of the 2012/13 Champions League final against Bayern.
In 2014, Lewandowski switched allegiances, joining Bayern Munich on a free transfer, and he went up another level, becoming the Bundesliga’s greatest foreign-born goalscorer and scoring 344 times in 375 matches in all competitions for the Bavarians, with whom he also won the Champions League.
Mario Gotze, who scored the winner for Germany in the 2014 World Cup final, was another more recent example of a player that moved from Dortmund to Bayern, having also been an integral part of Klopp's successful side.
Defender Mats Hummels, meanwhile, began his career at Bayern before moving to Dortmund permanently in 2009 and then returning to Bayern in 2016.
He hopped the fence once again in 2019, returning to the Signal Iduna Park.
The clubs have met twice in the Champions League and both were big occasions.
They first met in the competition in the 1997/98 campaign and it was the first time in the competition's history that two clubs from the same country had faced each other.
The first leg of that tie finished 0-0 with Dortmund winning the second leg 1-0 thanks to a strike from Stephane Chapuisat in extra time.
But Bayern got their revenge the next time the sides met in Europe's elite club competition in May 2013, when the teams met in the Champions League final.
It was a huge occasion for German football and marked the first time two German clubs had met in the competition's final.
Mario Mandzukic broke the deadlock for Bayern Munich in the game at Wembley Stadium before Dortmund equalised through Ilkay Gundogan's 68th-minute penalty.
But it was Bayern that were celebrating after Arjen Robben rolled the ball past Roman Weidenfeller in the 89th minute to seal the win.
A week later Bayern Munich beat Stuttgart in the final of the DFB Pokal and manager Jupp Heynckes went down in history as they became the first German team ever to win the treble.
Unsurprisingly given that he spent most of his career at both clubs, Lewandowski is Der Klassiker's all-time top goalscorer with 32 goals to his name.
The rest of the list is dominated by former Bayern Munich players with Gerd Muller having scored 15 times in the fixture and Thomas Muller netting on 12 occasions as of April 2022.