Portugal and Uruguay meet in the game of the day at the World Cup on Monday, while much-fancied Brazil also return to action as they seek a second successive win.
The Group H clash between Portugal and Uruguay closes out the programme on Monday, with the Group G encounter between Cameroon and Serbia kicking off the day at 10:00.
South Korea and Ghana are both looking to pick up their first victories of the competition at 13:00, ahead of Brazil and Switzerland squaring off at 16:00.
Portugal made a winning start to their World Cup campaign after surviving a late comeback from Ghana to pick up three points via a 3-2 triumph.
Cristiano Ronaldo opened the scoring from the penalty spot before Andre Ayew drew the Black Stars level with just over 15 minutes left to play.
Joao Felix and Rafael Leao each found the back of the net in the space of just two minutes to put Portugal in the driving seat, before an 89th-minute effort from Osman Bukari set up a tense finish.
Fernando Santos' side managed to hold out for the win and a second successive victory over Uruguay could guarantee a spot in the knockout phase.
Uruguay, however, aren't likely to make life easy for the European side as they look to pick a first win following a frustrating goalless draw with South Korea.
Neither Uruguay nor South Korea managed to a single shot on target in that encounter and a share of the points from probably the right and fair result.
Many predicted Portugal and Uruguay would be battling it out for top spot in this section so we could be set for fireworks when they meet in Lusail.
La Celeste ran out 2-1 winners over Portugal to dump them out of the 2018 World Cup in the last-16 when they last met, as a brace from Edinson Cavani cancelled out Pepe's goal.
The South Americans have earned a reputation for being tough to break down, keeping clean sheets in seven of their last eight games, and Portugal will have their work cut out in trying to get on the scoresheet.
Cameroon and Serbia both lost their first fixtures of the World Cup and will be desperate to pick up three points on Monday.
The Indomitable Lions were beaten 1-0 by Switzerland as Cameroon-born Breel Embolo netted the only goal of the game.
Serbia lost 2-0 against Brazil as a second-half brace from Richarlison saw the tournament favourites get off to a winning start.
That makes this clash hugely important for both as they know a second successive loss will make their task of advancing beyond the group extremely difficult.
Rigobert Song may be tempted to switch things up in attack after Eric Maxim Choupo-Moting struggled to impose himself and Vincent Aboubakar, who won the Golden Boot at the 2021 Africa Cup of Nations, could be preferred to lead the line.
Defensively, Cameroon didn't look too bad, but Serbia arguably offer more threat in the final third in comparison to Switzerland.
We can expect to see a very different approach from Serbia after they sat back in the hope of frustrating Brazil, something that worked out well in the first half, but ultimately the Selecao's talent came to the fore in the second period.
Serbia hitman Aleksandar Mitrovic was unable to get involved against Brazil but he might have a big role to play here and can be backed at 13/10 to score anytime.
Mitrovic scored eight times in helping Serbia to beat Portugal to top spot when qualifying for the World Cup and he has nine goals in 12 appearances for Fulham this season.
Juventus forward Dusan Vlahovic is also tipped to start against Cameroon after he was restricted to an outing from the bench against Brazil due to a lack of fitness.
The Eagles outscored France, Spain and Italy during their World Cup qualifying campaign and we should expect to see an expansive, front-foot approach on Monday.
South Korea's hopes of getting out of the group rely heavily on Tottenham ace Heung-Min Son, 13/8 to score anytime, but he was well off the pace when they played out a goalless draw against Uruguay.
A facial injury, sustained against Marseille in the Champions League on 1st November, saw his chances of featuring at the World Cup cast into doubt but he has made it after surgery and is wearing a protective mask.
He is undoubtedly South Korea's star man and they'll need a much-improved performance from him if they are to overcome an exciting Ghana.
The Black Stars gave Portugal a scare and can't be overlooked as potential contenders to qualify for the last-16.
They harried and hassled Portugal and will be full of energy once again when they look to avoid a second successive loss on Monday.
There was plenty to like about Ghana's approach in their opening game and, rated as 21/10 underdogs, they could be worth siding with.
Arriving at the World Cup as favourites, Brazil were always going to have a target on their back and it was no surprise to see Serbia attempt to stifle the South American giants with a defensive approach in their opening game.
They struggled to carve out chances in the opening 45 minutes but found the solution and moved through the gears in the second half, registering 19 shots, and a double from Richarlison saw the points sealed.
They will be without Neymar for the remaining group fixtures, but that might not be the biggest blow as he struggled to pull the strings against Serbia.
Richarlison, who has netted nine goals in his last seven international appearances, is their key man through the middle and is worth considering at 21/10 to net anytime.
Switzerland, having won their opening game, head into this clash knowing a point would put them in a good position to reach the last-16.
With that in mind, it wouldn't be a shock to see them try and follow Serbia's blueprint by putting plenty of bodies behind the ball.
The Swiss have reputation for being tough to break down, keeping clean sheets in three of their last five games, and we could see a similar game unfold.
Backing Draw-Brazil in the Half Time/Full Time market at 3/1 could be the way to go.