Friday is the final day of group matches at the World Cup when both Groups G and H will be completed, with Brazil, Uruguay, South Korea and Ghana all in action.
In Group G, Switzerland have the advantage as they look to join Brazil in the last-16, but they face a tough showdown with Serbia.
Meanwhile, in Group H, Uruguay know that they simply have to defeat Ghana if they are to avoid an early exit from the competition.
Brazil will be hoping to make it three wins from three in Qatar when they play Cameroon at 19:00 in Group G in Lusail.
So far the pre-tournament favourites have pretty much lived up to their billing, beating Serbia 2-0 and then Switzerland 1-0, and now they should have too much for a Cameroon side who have picked up just a point so far, albeit that was a 3-3 humdinger against Serbia.
Cameroon will be heading home unless they cause a major upset and win, although it will also depend on how the Swiss do against Serbia in the other game.
A familiar Brazil victory to nil, available at 6/5, is expected.
Serbia showed enough fight to restrict Brazil to two second-half goals in their opener before being involved in the game of the tournament so far when they threw away a 3-1 lead to draw 3-3 with Cameroon.
They have plenty of quality throughout their side, with skipper Dusan Tadic, who plies his trade with Ajax, Lazio forward Sergej Milinkovic-Savic and prolific Fulham frontman Aleksandar Mitrovic all key men.
They can get the better of the Swiss, with a win for them on offer at a tempting 13/8, as Murat Yakin's men have failed to impress so far, deploying a defensive approach which saw them edge out Cameroon 1-0 in their opener before a 1-0 defeat to Brazil followed.
This could be another explosive showdown between two old rivals with plenty at stake in this final Group H clash.
Both could still qualify, although Ghana are in the better position as they currently sit second behind already-through Portugal.
Ghana will progress to the last-16 with a win, while a draw will also do as long as South Korea do not beat Portugal by two goals or more in the other game.
Uruguay's clearest route to the next round is to beat Ghana, while hoping that South Korea fail to beat Portugal, but goal difference and even goals scored could come into the equation, depending on how both matches play out on what should be a dramatic afternoon.
This is a repeat of their famous World Cup quarter-final in 2010 when Uruguay eventually went through on penalties, but only after Luis Suarez was sent off for denying Ghana a late winner when he deliberately handled the ball on the line, only for Asamoah Gyan to sensationally miss the subsequent spot-kick.
Portugal are already through but will be looking for a win to secure top spot, while South Korea must win to stand any chance of joining them in the knockout stages.
It could come down to goals scored and goal difference in what has been a tight group and Paulo Bento's side will be hoping Portugal ease off and make plenty of changes for the final group encounter having already booked their passage.
Bento, ironically born in Portugal, has overseen an uninspiring 0-0 draw against Uruguay and then a 3-2 defeat for South Korea against Ghana - results which have left all three teams in with a chance of progressing.
A win for South Korea looks decent value at 10/3.