Panic Attack is aiming to buck an almighty trend in the Grand National this weekend.
Coming off the back of a stellar season where she has landed not one, but two major handicaps, many are forecasting that she could even be sent of as favourite for the world's most famous steeplechase.
Down the years, mares have had a desperately poor record in the race but, at the moment, if you could pick one British trainer to change that; it would be Dan Skelton.
You have to go all the way back to 1951 to find the last mare successful in the Grand National when Nickel Coin, trained by Jack O'Donoghue, won at 40/1.
Her historic success makes her a famous name around Aintree and she now has a race ran in her honour that takes place on the opening day of the Grand National Festival.
Although the last 75 years has been completely barren, mares faired pretty well in the early runnings of the race.
13 in total have landed the spoils; 10 of these coming during the 1800s.
Charity was the first, all the way back in 1841, but then the likes of Empress, Zoedone and Frigate ensured that the 1880s was strong decade for for female runners.
Charity (1841)
Miss Mowbray (1852)
Anatis (1860)
Jealousy (1861)
Emblem (1863)
Emblematic (1864)
Casse Tete (1872)
Empress (1880)
Zoedone (1883)
Frigate (1889)
Shannon Lass (1902)
Sheila's Cottage (1948)
Nickel Coin (1951)
There wasn't a single mare to take their chance in last year's renewal but two had a go in 2024.
Both ran well to a point with Galia Des Liteaux finishing eighth ahead of Limerick Lace who trailed behind in 10th after making a bad blunder four out.
Snow Leopardess went off 10/1 for the race in 2022 after winning the Becher earlier that same season but she failed to show her true running after assuming a position as antepost favourite for a good while in the build-up to the day.