Arsenal marked reaching the half-way point of their season by getting to 50 points with Eddie Nketiah's late winner securing a 3-2 triumph in a breathless contest at home to Manchester United.
The Gunners started the game only two points ahead of title rivals Manchester City following the champions' easy 3-0 win over Wolves, but showed few signs that the pressure might be getting to them.
Marcus Rashford's stunning strike might have unsettled the Emirates as it fizzed past Aaron Ramsdale early on, but Nketiah's close-range header levelled matters just seven minutes later to ease any nerves.
Bukayo Saka gave the Gunners the lead not long after the restart with a screamer from distance before Lisandro Martinez tied things up at the hour mark, after capitalising on a Ramsdale mistake from a corner.
However, with normal time almost up, Nketiah flicked home his second of the game to send the home crowd into raptures, despite a nervy VAR check for offside.
Mikel Arteta's men are once again five points clear of City with a game in hand, while United's title hopes took another big hit - they are now 11 points adrift of the leaders while they are behind third-placed Newcastle on goal difference.
The Arsenal bandwagon continues to roll along nicely and they re-established what could be a significant advantage over City once again with the five-goal cracker.
Arteta's men were seeking revenge on United for their 3-1 defeat back in September at Old Trafford - still the only time they have lost a Premier League game all season.
Even though United did enough to score twice, Arsenal did not fall back into their shell and kept pushing and pushing for a winner.
That duly came through Nketiah, who has been a phenomenal deputy for the injured Gabriel Jesus - so much so that the Brazilian might not automatically get back in the team when he is fit again.
New signing Leandro Trossard made a second-half debut in what was a hugely satisfying day at the office. Dreams of a first title win in 19 years are inching closer, even with half the season remaining.
City won at home for the second time this week with Erling Haaland sending another defence packing with another hat-trick on Sunday against Wolves.
Amazingly, there has been some debate and conjecture over whether City are a better overall team with Haaland in it but the Norwegian made those claims look laughable against Julen Lopetegui's men.
It marked a fourth Premier League hat-trick of the season for the young striker, all of which have been at the Etihad, and he has now scored 31 goals across all competitions for City.
The Premier League record of 32 set by Mohamed Salah - for a 38-game season - looks certain to be broken and a genuine aim for him could be to get to a half-century - priced at 8/1 - a total that perhaps even his most fervent backers would have struggled to foresee when he arrived in England in the summer.
Two of the big six met on Saturday lunchtime but it never looked like a game that was going to spark into life due to the form of both Liverpool and Chelsea.
The pair drew 0-0 in both domestic cup finals last season and another goalless slug-fest followed at Anfield, with an early strike from Kai Havertz chalked off by VAR for offside.
Liverpool are now winless in their last three games while Chelsea have won only two of six since they returned to action from the World Cup break. In terms of getting into the top four, Liverpool are priced at 2/1 while Chelsea are now as big as 7/1.
New signing Mykhailo Mudryk's sparkling second-half cameo will give Chelsea some hope but both sides are in danger of missing out on top-level European football.
Everton's season plunged to a new low after they were beaten 2-0 by West Ham at the London Stadium in what was another meek and toothless display from the Toffees.
Jarrod Bowen's first-half brace meant West Ham grabbed three vital points at the expense of their relegation rivals, who are facing the genuine threat of EFL football and being outside of the top flight for the first time in the Premier League era.
The malaise around the club continues and the board are reportedly reviewing recent performances as well as Lampard’s own position at the helm.
Their lack of attacking threat has been evident all season and they have scored only four goals in their last eight Premier League games, since their previous victory over Crystal Palace in mid-October.
As a result, Lampard's men are now 8/13 to be relegated.
It proved to be a good weekend for the Hammers with none of their other relegation rivals winning.
Wolves were beaten, as expected, by City while Southampton remain bottom after a narrow 1-0 loss at home to Aston Villa.
Sam Surridge's late equaliser meant Nottingham Forest and Bournemouth took points off each other while Leeds failed to break down Brentford in a goalless draw at Elland Road.