The US Open has reached the last-16 stage and all eyes will be on world number one Daniil Medvedev when he faces Wimbledon runner-up Nick Kyrgios.
Medvedev is the defending champion at Flushing Meadows and is 15/8 to be crowned champion again, but the Russian could have asked for an easier fourth-round opponent.
Rafael Nadal, Carlos Alcaraz and Jannik Sinner are also still involved in the US Open men's draw, while seventh seed Cameron Norrie is the last Briton standing in New York and he takes on Andrey Rublev in the next round.
Polish world number one Iga Swiatek heads the women's betting at 15/8 and meets German youngster Jule Niemeier in her next game, before a potential crunch quarter-final with Petra Kvitova.
Home favourite Cori Gauff and in-form Frenchwoman Caroline Garcia look the two standout performers in the bottom half of the draw and they could also be about to meet in the last eight.
Medvedev out for revenge on Kyrgios
| What | Daniil Medvedev vs. Nick Kyrgios |
| Where | USTA Billie Jean King National Tennis Center, Flushing Meadows, New York |
| When | 00:00, Monday 5th September 2022 |
| How to watch | Amazon Prime, bet365 Sports Live Streaming |
| Odds: | Daniil Medvedev 8/15, Nick Kyrgios 6/4 |
Medvedev, who is the defending champion and world number one, has eased into the last-16 without dropping a set but now comes his toughest test yet.
Wins over Stefan Kozlov, Arthur Rinderknech and Yibing Wu were not a test of his title credentials, but a clash with fired-up Australian Kyrgios is.
These two met in Montreal in August and it was Kyrgios who came out on top, as he came from behind to win 6-7 6-4 6-2.
They also locked horns at the Australian Open in January, with Medvedev prevailing in four sets, but it is fair to say that Kyrgios' levels have been significantly raised since then.
The Australian looks more focused - highlighted by the fact he has lost only three of his last 21 completed matches - and he will be determined to prove his critics wrong against the current best player on the planet.
Kyrgios showed what he was capable of when in the mood to perform when finishing runner-up at Wimbledon in July and he will fancy his chances of mastering Medvedev.
The winner of this titanic tussle will face Pablo Carreno Busta or Karen Khachanov in the quarter-final, with Berrettini or Casper Ruud likely to be lurking in the last four.
Nadal and Alcaraz on course for semi-final clash
All tennis fans will be hoping to see an all-Spanish semi-final between Nadal and Alcaraz and it is still very much on the cards.
Nadal is the master and is the most decorated player in history with 22 Grand Slam titles, while 19-year-old Alcaraz is still a student of the game and one of the rising stars.
It's unlikely Alcaraz will ever achieve what his classy compatriot Nadal has done, but he still looks a future champion and is a candidate for success at New York.
Having won two of the three Grand Slam titles this year in Australia and France, Nadal is 3/1 for another Major victory while Alcaraz is a 4/1 chance in his pursuit of a first title at the top.
First Nadal has to overcome American Frances Tiafoe and then one of Rublev or Norrie, whereas Alcaraz has to conquer 2014 champion Cilic before taking on either Ilya Ivashka or fierce rival Sinner.
Nadal is 1/6 to see off Tiafoe, while Alcaraz is 1/4 to topple Cilic.
Swiatek has tough route to the final
| What | Iga Swiatek v Jule Niemeier |
| Where | USTA Billie Jean King National Tennis Center, Flushing Meadows, New York |
| When | 16:00, Monday 5th September 2022 |
| How to watch | Amazon Prime |
| Odds: | Iga Swiatek 1/6, Jule Niemeier 4/1 |
Women's world number one Swiatek has won her opening three games in New York in straight sets and the prolific Pole is much fancied to go on and be crowned champion.
Next up for Swiatek is young German Niemeier, who made the quarter-finals at Wimbledon, and the top seed is widely expected to come through that test.
Kvitova or Jessica Pegula would be waiting in the quarter-final, however, while the likes of Danielle Collins, Aryna Sabalenka, Victoria Azarenka and Karolina Pliskova are also still in Swiatek's half of the draw, showing just how tough she may have it.
At her current title odds, she therefore makes little appeal, with the bottom half easier in which to pinpoint weaknesses.
Garcia showcasing title credentials
Former world number four Garcia is in the form of her life and on current evidence it is going to take something special to stop her.
The Frenchwoman is on a remarkable run, having lost only four of her 33 competitive matches since the middle of June and that form is showing no signs of relenting..
Garcia warmed up for the US Open with a title triumph in Cincinnati - already her third piece of silverware this year - and she has yet to drop a set in New York.
The 17th seed's list of scalps include former champion Bianca Andreescu, who she brushed aside 6-3 6-2, and next up is home hope Alison Riske-Amritraj.
Garcia is 2/9 to beat the American and 6/1 for Grand Slam glory, while a potential quarter-final with Gauff looks mouthwatering and that could well decide who makes the title decider.
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