Brandon Moreno will go up against Brandon Royval for the second time when the pair headline February's' UFC Fight Night 237 - marking the organisation's sixth visit to Mexico City.
Former flyweight champion Moreno will be looking for another victory over Royval after they first went head-to-head at UFC 255 in November 2020, when Moreno won by first round TKO.
Royval has stepped in to replace Amir Albazi, who was Moreno's original opponent but has been forced to withdraw due to injury.
The Flyweight fight takes place on a card also featuring a rematch between former interim UFC featherweight champion Yair Rodriguez and former title challenger Brian Ortega.
Moreno v Royval is part of the UFC Fight Night card being held on Saturday 24th February CST.
It is, therefore, scheduled to run overnight and into Sunday morning GMT.
The preliminary card is set to begin at 00:00 GMT, with the main card slated to start at 03:00 GMT.
UFC Fight Night 237 will be held at Arena CDMX in Mexico City, marking the promotion's sixth visit to the Mexican capital and first since 2019.
The Arena CDMX, formerly known as Arena Ciudad de Mexico, was opened in March 2012 and has hosted the UFC's previous five trips to Mexico.
It has also hosted boxing matches and NBA fixtures, as well as other sports and entertainment events.
Fans in the UK can watch all the action on TNT Sports, formerly BT Sport, while it is also available via UFC Fight Pass.
The card can also be watched on the UFC's mobile app.
No belts will be on the line in Mexico City, although the winner could place themselves in line for a title shot against current flyweight champion Alexandre Pantoja.
Moreno is the favourite to win the fight at 2/5, while Royval is to come out on top in the battle of the Brandon's.
Home favourite Moreno is #1 in the UFC's flyweight division and possesses a 21-7-2 record in MMA.
His last fight ended in a split decision defeat to Pantoja, as he lost his UFC Flyweight title. That result ended a two-fight winning streak that had seen him beat Kai Kara-France to win the interim title before taking the belt in his rematch against Deiveson Figueiredo.
He and Figueiredo had previously traded the belt, with the first of their four fights ending in a draw before Moreno beat the Brazilian in their second showdown.
That is one of two draws on his record, the other coming against Askar Askarov in Mexico City in 2019, while he has won 21 times and lost on seven occasions, including against Sergio Pettis at February's venue in August 2017.
Royval has an MMA record of 22 fights, 15 victories - of which five have been by knockout - and seven defeats.
He made his UFC debut in May 2020 at UFC on ESPN: Woodley v Burns against Tim Elliott and impressed, winning the fight via submission in the second round to earn him a Fight of the Night award.
After then overcoming Kai Kara-France in his next bout, he lost to Moreno at UFC 255.
He has since got back on track with victories over Rogerio Bontorin, Matt Schnell and Matheus Nicolau, but, most recently, lost to Alexandre Pantoja at UFC 296 in December.
The venue means the event inevitably has a local flavour, with Mexican fighters involved in all five bouts on the main card.
Home hope and #2 featherweight Rodriguez (15-4-1 NC) takes on #3 Ortega (15-3-1 NC). The pair previously met in New York in July 2022 when the Mexican won by first round TKO due to his opponent suffering a shoulder injury.
Their rematch will mark the fourth time a non-main event and non-title bout has been scheduled for five rounds and was previously expected to be a co-main event on the night.
Among the other fights planned for earlier in the night, Mexico's Yazmin Jauregui (10-1) will look to respond to losing her unbeaten record to Denise Gomes last July when she takes on fellow strawweight Sam Hughes.
The American is 8-5 for her career and was last seen recording a unanimous decision success over Jaqueline Amorim at UFC 287 in April 2023.
There is also a Bantamweight showdown between Cristian Quinonez and Raoni Barcelos, and two Lightweight fights between Daniel Zellhuber and Francisco Prado and Manuel Torres and Chris Duncan.
On a busy night in Mexico City, there are flyweight bouts between Edgar Chairez and Brazil's Daniel Lacerda, too, while Victor Altamirano faces another Brazilian in Felipe Dos Santos.