British number one Draper had to dig deep to fend off the challenge of Jaume Munar in the opening round in Cincinnati but he should have little to fear against Stefanos Tsitsipas, who has been struggling to put his best foot forward of late.
Tsitsipas also needed three sets in his opening duel with Jan-Lennard Struff, with the ninth seed coming from a set down before getting over the line.
With Tsitsipas having endured a shock defeat to Japanese veteran Kei Nishikori in Montreal prior to that, there is an air of vulnerability about the Greek star and it is something Draper may be able to expose.
On the whole, the Brit has had a stellar season, having finished runner-up in Adelaide and claiming his maiden ATP Tour title in Stuttgart, and the 22-year-old is capable of going to even greater heights.
The Londoner has a big serve and powerful groundstrokes, some of the attributes required to be a driving success, and he did topple Tsitsipas in their only previous meeting in Montreal two summers ago.
Jack Draper to win - 11/8
These two have only met once before and it came on a hard court around this time in the year in Montreal two seasons ago, with Draper springing a surprise in a 7-5 7-6 victory.
Since then, Draper has improved markedly while Tsitsipas has stalled, slipping from world number three to world number 11 and he is regularly blighted by inconsistencies.
The 26-year-old has plenty of time to sort things out and he is too good not to be challenging for Grand Slam titles, but recent form has to be a concern and he remains at his most potent on clay.
After suffering a surprise 6-4 6-4 defeat to 34-year-old Nishikori in Montreal last week, Tsitsipas parted company with his coach - who was also his father - and replaced him with Greek Davis Cup captain Dimitris Hadjinikolaou.
That shows that Tsitsipas is doubting his current performance levels and felt that change was needed.
The Greek star started things with a victory over Struff but he had to fall a set behind before kicking into gear and his German victim has never been the most convincing on a hard court.
So Tsitsipas should be expecting a stern test from Draper, who claims he has been working hard in the build up to Cincinnati having suffered an early elimination of his own in Montreal.
The world number 28 showed great character in his three-set win over round-one opponent Munar, who had claimed two strong scalps in qualifying, and he was serving strong with 13 aces.
With Tsitsipas having lost four of his last seven hard-court encounters, he is currently operating way below his world ranking and he will be well aware that Draper has the weapons needed to bring him down.
That adds to the pressure of the occasion and Draper, who has won 10 of his 16 matches on this speedier surface this season, looks in a better mindset currently.
20+ aces in the match - 1/1
Both players excel on serve and, with the possibility of three sets looking highly likely, backing there to be 20+ aces across the contest has to appeal.
Draper fired in 13 aces in his opening-round win over Munar while Tsitsipas racked up 18 aces in his three-set victory over Struff, with the contest featuring 27 in total.
Draper has had 10 or more aces in three of his last four hard-court matches - his three-set defeat to Nicolas Jarry in Miami in March featured 38 - and he knows he has to keep service games short and sweet if he is to prevail.
When these two clashed in Canada in 2022 there were 13 aces, but that was settled in straight sets and there is every possibility that this goes much longer.
With both players strong on serve, the possibility of a tiebreak looks likely too, something which would help this bet get that bit closer to the total.
Read more tennis betting tips and predictions on site.
Jack Draper - 11/8
Stefanos Tsitsipas - 4/7
View the full market and more odds for Jack Draper v Stefanos Tsitsipas on site.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.