Holders Liverpool look set to have their work cut out when they continue their defence of the FA Cup at Brighton on Sunday.
Stoke will also be aiming to avoid an upset at home to Stevenage, while Wrexham will be looking to cause another shock against Sheffield United.
There is also action on Monday, as West Ham head to Derby and all the games can be watched on bet365's Sports Live Streaming.
|What||Brighton v Liverpool, FA Cup fourth round|
|Where||The Amex, Brighton|
|When||13:30, Sunday 29th January|
|How to watch||ITV1 and and bet365's Sports Live Streaming|
|Odds||Brighton 8/5, Draw 11/4, Liverpool 31/20|
Brighton have been a thorn in Liverpool's side this season, drawing 3-3 at Anfield in October before outclassing them 3-0 a fortnight ago at the Amex.
In fact, the Seagulls have lost just one of the pair's last six meetings in all competitions and are 8/5 To Win Match within 90 minutes.
That looks like a handy price, especially when you assess that the holders have won just one of their last five in all competitions and could well be prioritising the Premier League with them 10 points behind fourth-placed Manchester United.
Brighton are also well in the mix for the European places but having also beaten Chelsea and Manchester United in the league, and Arsenal in the EFL Cup, the 1983 runners-up may feel they can go deep in this competition, with them 16/1 To Win Outright.
A player who has caught the eye this season, including scoring a brace in that recent 3-0 win, is Solly March. The winger is 5/1 as an Anytime Goalscorer and will certainly test a defence that has looked far from secure, despite keeping clean sheets in their last two games.
Brighton themselves have only recorded one shutout in their last six so an open game is promised and a home win and both to score in the Result / Both Teams to Score may well appeal at 10/3.
|What||Stoke City v Stevenage, FA Cup fourth round|
|Where||Bet365 Stadium, Stoke|
|When||14:00, Sunday 29th January|
|How to watch||bet365's Sports Live Streaming|
|Odds||Stoke City 8/11, Draw 14/5, Stevenage 4/1|
After beating Hartlepool 3-0 in the last round, Stoke take on another League Two side when Stevenage come to town on Sunday.
Steve Evans' men are going well in the fourth tier, currently sitting second and are hoping to become the first team to win away games in the first four rounds in a single season.
They are 4/1 to do that and have already caused a huge upset by beating Aston Villa in the third round.
Stevenage are also unbeaten in seven on the road in League Two, but that run includes five draws and they take on a team who won their last home match 4-0 against Reading last Saturday.
Stoke also won the pair's only ever meeting 4-0 and reached the fifth round last season before going down 2-1 at Crystal Palace.
Another close encounter is likely in the Potteries but the hosts could sneak it, with the home win and over 2.5 goals is 15/8.
Saturday FA Cup preview: Manchester United to continue their trophy charge at home
EFL Cup: Nick Pope's improvement key to Newcastle's chances of success
|What||Wrexham v Sheffield United, FA Cup fourth round|
|Where||The Racecourse Ground, Wrexham|
|When||16:30, Sunday 29th January|
|How to watch||BBC1 and bet365's Sports Live Streaming|
|Odds||Wrexham 7/2, Draw 13/5, Sheffield United 5/6|
The competition's top scorer will be in action on Sunday when Wrexham's Paul Mullin runs out against Sheffield United.
The 28-year-old has scored six FA Cup goals this season and is 11/5 as an Anytime Goalscorer.
The most recent of those goals came in the 4-3 third round win over another Championship side, Coventry, and he could become the first player to score in the first four rounds of the competition since 1984/85.
It is hardly a secret that Wrexham's famous owners have invested heavily and with them sat top of the National League, their squad looks too good for that division and potentially even the one above it.
Mullin is certainly of that level, having dropped out of the EFL in 2021 on the back of winning the league Two Player of the Year award and will look to test a Blades defence experiencing somewhat of an injury crisis.
However, they sit second in the Championship and have progressed from seven of their last eight ties against non-league opposition.
Wrexham's quality means they should be better than the other teams they have faced in that time and are the first non-league side in two decades to score three or more goals in the first three rounds of the competition.
Only 3.5 goals could be a contender at 7/4 but Paul Heckingbottom's men should have too much and are 13/5 in the Result / Both Teams to Score market.
|What||Derby v West Ham, FA Cup fourth round|
|Where||Pride Park, Derby|
|When||19:45, Monday 30th January|
|How to watch||ITV4 and bet365's Sports Live Streaming|
|Odds||Derby 10/3, Draw 11/4, West Ham 4/5|
Finally to Monday's match and there will be a whiff of magic in the air as League One promotion hopefuls Derby take on Premier League strugglers West Ham.
The Rams are going extremely well, with them unbeaten within 90 minutes since 21st October and have beaten Torquay, Newport and Barnsley to reach this stage.
Paul Warne's side have also won their last five at home and will hope to catch the Hammers out with David Moyes' men having bigger priorities.
Last Saturday's 2-0 win over Everton helped them move up to 16th in the Premier League but may be distracted with their next three league games coming against Newcastle, Chelsea and Tottenham.
While they beat Brentford in the last round, they have been upset-prone over recent years, requiring extra-time to get past non-league Kidderminster last term, while they lost to AFC Wimbledon at this stage in 2018/19.
The odds are rightly in West Ham's favour but they will need to be careful against the Rams, who have a familiar face leading the line in the form of David McGoldrick.
McGoldrick has scored twice to date in this competition and is 10/3 Anytime Goalscorer.
However, the Hammers' class means they should prevail and they are 4/5 in the Full Time Result market.