Marcelo Bielsa's Uruguay will strive to continue their strong start to World Cup qualifying when they host Paraguay in Montevideo.
Uruguay are currently second in South American World Cup qualifying, losing just once in six matches against Ecuador.
Paraguay have endured contrasting fortunes, with Gustavo Alfaro's side sat seventh in the table with just one win in six qualifiers.
Uruguay v Paraguay will be available to watch via bet365's Live Streaming Service.
Uruguay v Paraguay will kick off at 00:30 BST at Estadio Centenario on Saturday 7th September.
The most recent meeting between Uruguay and Paraguay came in a 2022 World Cup qualifier in January 2022, with Luis Suarez netting the winner in a 1-0 win for La Celeste in Asuncion.
Uruguay head into this match against Paraguay 10 games unbeaten against their visitors, with La Albirroja's last victory way back in October 2007 in a World Cup qualifier.
Uruguay wins | 34 |
Draws | 18 |
Paraguay wins | 25 |
(*H2H stats refer to all competitions).
Luis Suarez is expected to start his last ever match for Uruguay after announcing his imminent retirement from international football.
Darwin Nunez, Rodrigo Bentancur, Ronald Araujo, Jose Gimenez and Mathias Oliveira are all suspended.
Matias Vina, Giorgian de Arrascaeta, Federico Vinas and Nicolas de la Cruz will miss the meeting with Paraguay due to injury.
Paraguay manager Gustavo Alfaro has no new injury concerns ahead of this match against Uruguay.