Dave Challinor takes charge of his first League One fixture since being named Sheffield Wednesday boss as the Owls welcome Plymouth Argyle to Hillsborough.
Challinor was unveiled as Henrik Pedersen's successor at the start of November, but his reign commenced in eye-opening fashion as Wednesday were eliminated in the FA Cup first round by Oldham Athletic.
The defeat served an apt reminder of the scale of the job Challinor faces, but the former Stockport County supremo will be eager to mark his first home match with a victory.
Visitors Plymouth are just three points off the League One automatic promotion places after they bounced back from consecutive defeats to Huddersfield Town and Stevenage by claiming four points from a possible six against Cambridge United and Reading.
Sheffield Wednesday v Plymouth Argyle team news
Wednesday have been boosted by the availability of Joe Lumley and Jamal Lowe, who return from their respective suspensions.
Challinor also has Louie Barry to call on from the bench as the former Stockport forward steps up his return from injury.
Plymouth boss Tom Cleverley has made four changes from the side that were held to a goalless draw against Reading with Murphy Cooper returning between the sticks.
Ronan Curtis starts on the flank, while Malachi Boateng slots into the midfield with Tyreeq Bakinson absent. Alan Hartridge starts in central defence.
Confirmed Sheffield Wednesday line-up
Lumley; Valery, Cooper, Bernard, Swinkels; Mitchell, Bannan; Heskey, Slattery, Lowe; Keillor-Dunn.
Substitutes: Trueman, Palmer, Santos, Weaver, Thornton, Gray, Barry.
Confirmed Plymouth Argyle line-up
Cooper; Harding, Ross, Hartridge, MacKenzie; Amaechi, Boateng, White, Curtis; Evans, Ibrahim.
Substitutes: Storer, Irow, Watts, Oseni, Campbell, Mwaro, Maund.
