Lucinda Russell won Warwick's Classic Chase with One For Arthur in 2017 and hopes to repeat the trick five years later with Corach Rambler.
The eight-year-old novice chaser, 5/1 to win on Saturday, is set to carry topweight in the big handicap over 3m5f following wins at Aintree and Cheltenham earlier this season.
Ridden by Derek Fox, Corach Rambler was value for more than the winning margin suggests at Cheltenham after wandering about and idling on the run-in.
The handicapper reacted by putting him up 8lb, but Russell is hoping she has made the right decision in going for this big prize.
One For Arthur subsequently went on to win the Grand National after his Classic Chase win and while Corach Rambler will not be taking that route this season, he could still go to Cheltenham for the Festival in March.
Russell said: "We didn't make a decision until five minutes before the deadline, we'd been thinking about it for a long time. Threeunderthrufive beat us in a novice hurdle at Musselburgh and we were worried he'd beat us again.
"We looked at the handicap and thought it's such a good prize, he's won two, so why not go for another? Although he's got top weight [11st 12lb] he deserves to be there and if he can improve a bit for the step up in trip it will open more doors.
"He won't be going for the National this year. I'd love to take him to Cheltenham again, whether that's for a handicap or novice, and then we could look at the Scottish National meeting."