Sale Sharks and Harlequins commence their respective Premiership campaigns when the two sides meet at the Salford Community Stadium on Sunday.
Sale finished third last term before bowing out in the play-off semi-final against runners up Bath, while Harlequins failed to secure a top-four finish after crushing back-to-back defeats against Exeter and Bristol to end the season.
Sale Sharks v Harlequins will be be available to watch live on TNT Sports 1 and Discovery+ in the UK.
Sale Sharks v Harlequins takes place at 15:00 BST on Sunday 22nd September and the match will be played at the Salford Community Stadium.
Sale and Harlequins have shared two wins apiece across their last four meetings, with the Sharks prevailing 37-31 in their last encounter after Harlequins were victorious 36-3 in the reverse fixture.
Sale boast an impressive record on the opening day having started off their last five seasons with a victory.