Joe Schmidt's tenure as Australia boss began with a hard-fought win over Wales last weekend and they will square off for a second time on Saturday.
The Wallabies got revenge on Wales for last year's World Cup humiliation in France, while Warren Gatland's side now find themselves on an abysmal run of 14 losses in 20 games in his second tenure.
Australia v Wales will be shown live on Sky Sports Main Event and Sky Sports Action.
Australia v Wales kicks off at 10:45 UK time on Saturday 13th July. The second Test will be played at AAMI Park in Melbourne, Australia.
The Wallabies enjoy a vastly superior head-to-head record over Wales, with 32 victories from their 47 total meetings in all competitions.
They met in last year's World Cup as Gatland's men produced a dominant display to thrash the Wallabies 40-6 - a result that all but eliminated Australia from the tournament in France.
Australia have replaced Eddie Jones with Schmidt as boss since, and they ran out 25-16 winners in the first Test of this series in Sydney last weekend.
Australia wins | 32 |
Draws | 1 |
Wales wins | 14 |
*H2H stats refer to all competitions
Read the latest tips, predictions and odds for Australia v Wales.
Schmidt makes a single change for his second game in charge, Charlie Cale making a first start at number eight with Rob Valetini pushed to blind-side flanker.
Newly-appointed skipper Liam Wright has been ruled out with a shoulder injury, leaving veteran prop James Slipper to captain Australia.
Full-back Cameron Winnett and flanker James Botham will replace the injured Josh Hathaway and Aaron Wainwright in Melbourne.
Full-back Liam Williams switches to wing, with flanker Taine Plumtree slotting in at number eight. Botham comes into the back row at blind-side flanker, with Cardiff number eight Mackenzie Martin promoted to the replacements bench.