Brazil kick off their World Cup campaign on Thursday and Cristiano Ronaldo's are also in action in Qatar.
Portugal fell at the same hurdle at Euro 2020, losing 1-0 to Belgium after a 3-0 win over Hungary, a 4-2 defeat to Germany and a 2-2 draw with , in which Cristiano Ronaldo scored two penalties, in three entertaining group games.
United teammate Bruno Fernandes scored twice in that victory but Ronaldo, who has amassed 117 goals in 191 caps for his country, should be fit to start against Ghana and he is to be the First Goalscorer.
Three of Portugal's last four international wins, against Nigeria, the Czech Republic and , have been by a 4-0 margin and that outcome can be backed at 16/1 in the Correct Score market.
Ghana have some form players in their ranks with Athletic Bilbao stalwart Inaki Williams, who recently switched his international allegiance from Spain, set to lead the line and Arsenal's Thomas Partey at the heart of their midfield. Mohammad Kudus, who has impressed for Ajax in this season's , is 16/1 to be First Goalscorer.
However, Portugal's defence is solid and both teams have scored in only one of their last eight internationals, a 1-1 Nations League draw with Spain, so backing Portugal to win to nil at could be the way to go.
The Serbs are 11/2 to beat Brazil in Lusail and both of these teams qualified for the finals in impressive style.
Brazil conceded only five goals in 17 qualifying matches, winning 14 and drawing three, while Serbia were also unbeaten in their qualifying campaign, finishing top of European Group A ahead of Portugal.
As that price suggests, Serbia are expected to put up some decent resistance to the trophy favourites, especially if striker Aleksandar Mitrovic and Juventus forward Dusan Vlahovic are fit enough to start.
Brazil, of course, have an embarrassment of attacking riches but Neymar, who has been in prolific Ligue 1 form for this term, remains their main man and is 15/4 to be the First Goalscorer in Lusail.
It is worth noting that Neymar has scored five penalties in Brazil's last six internationals, and Philippe Coutinho also converted a spot-kick during that run, so the on offer about Brazil in the To Score A Penalty market could be worth a bet.