Aston Villa kicked off with an impressive 2-1 triumph at West Ham but they face an even bigger challenge against Arsenal at Villa Park.
The Gunners are determined to make a bold bid for the title and they began with a routine 2-0 victory over Wolves at the Emirates Stadium.
Saturday's match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League in the UK.
The fixture kicks off at 17:30 BST on Saturday 24th August and it is being held at Villa Park in Birmingham, England.
Aston Villa had gone six competitive games without a victory before defeating West Ham last weekend. Arsenal are on a seven-match winning streak.
They have played each other on 203 occasions with Aston Villa winning 71 times and Arsenal recording 87 victories.
Aston Villa won both league meetings last season without conceding, winning 1-0 at Villa Park in December before recording a 2-0 success at the Emirates in April.
Aston Villa wins | 71 |
Draws | 45 |
Arsenal wins | 87 |
*H2H stats refer to all competitions
Read the latest tips, predictions and odds for Aston Villa v Arsenal.
Matty Cash (knock) is a doubt and Boubacar Kamara and Tyrone Mings (both knee) are long-term absentees.
Fabio Vieira (hip) is close to full fitness but Kieran Tierney (hamstring) and Takehiro Tomiyasu (knee) are unavailable.