Ollie Watkins has withdrawn from the England squad to face Andorra and Senegal after suffering a minor injury.
The Aston Villa striker will miss the World Cup qualifier against Andorra and next week's friendly against Senegal, leaving Thomas Tuchel with captain Harry Kane and Ivan Toney as the only forwards left in the England squad.
Reports suggest no initial replacement is expected to be called up for the 29-year-old, who has netted five times in 18 games for the Three Lions.
Record goalscorer Kane is expected to lead the line for England in Barcelona, but Toney may get a chance to impress Tuchel in Tuesday's friendly after being called up for the first time since the Euros last summer.
Andorra (a) - World Cup qualifier - Saturday 7th June (17:00 BST)
Senegal (h) - International friendly - Tuesday 10th June (19:45 BST)
Andorra (h) - World Cup qualifier - Saturday 6th September (17:00 BST)
Serbia (a) - World Cup qualifier - Tuesday 9th September (19:45 BST)