Buffalo Bills v San Francisco 49ers: Prediction, Tips and Odds

Sub-zero temperatures await the visiting San Francisco 49ers when they head east to face the in-form Buffalo Bills at Highmark Stadium in the early hours of Monday morning.

After losing their last two games against the Seattle Seahawks and the Green Bay Packers, last year’s NFL Championship runners-up are at risk of not even making the play-offs this season.

Lying bottom of the NFC West with a 5-6 record, the 49ers still have everything to play for, but each defeat gives the opportunity for the likes of Seattle, the Arizona Cardinals and the LA Rams to pull further ahead.

In contrast, Buffalo are one of the form teams in the NFL, with quarterback Josh Allen guiding his side to six consecutive wins going into Week 13.

With a 9-2 record, Allen and the Bills will be eager to pile even more pressure on the 49ers and their quarterback Brock Purdy, who is nursing a shoulder injury ahead of a chilly trip to Orchard Park on Monday.

Buffalo Bills v San Francisco 49ers prop bets - tips and predictions

James Cook anytime touchdown scorer - 10/11

With snow expected in New York state and temperatures below freezing, both teams will rely heavily on their running game for crucial yards and points.

James Cook has enjoyed an impressive season for the Bills, with the running back having already scored 10 touchdowns this term.

With two touchdowns to his name in an impressive 30-21 win over reigning champions the Kansas City Chiefs last time out, Cook goes into this game in hot form.

With confidence on his side, look to Cook in the anytime touchdown-scorer market to keep up his run and add to his impressive tally for the season.

George Kittle anytime touchdown scorer - 11/4

While the 49ers will also look to their star running back Christian McCaffrey for points on Monday, the San Francisco star is a short price at 8/11 in the anytime touchdown market.

Tight end George Kittle offers a far more attractive price to score a touchdown at Highmark Stadium, especially since he has already scored 10 this season.

While looking to wide receivers will be riskier in the conditions expected in this game, shorter passes to tight ends should be a more efficient way of gaining precious yards and scoring points.

Kittle has already proved himself to be an effective weapon in the 49ers’ offence this season and he’s good value to score again on Monday.

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Buffalo Bills v San Francisco 49ers Money line, spread, over/under

	Money Line	Spread	Over/Under
Bills	1/3	-6.5 - 10/11	Over 45.0 - 10/11
49ers	12/5	+6.5 - 10/11	Under 45.0 - 10/11

Buffalo Bills -6.5 - 10/11

With a perfect five-from-five at home this season and currently on a six-game winning streak, it’s hard to look past the Bills claiming another victory on Monday.

Well used to the cold conditions at Highmark Stadium, the Bills know exactly how to play in the snow, in contrast to their opponents from sunny California.

With Purdy’s fitness uncertain, it’s hard to see the 49ers putting up enough points against this formidable Bills’ defence.

Buffalo have been in free-scoring form of late, scoring 30 points in all of their last three games and they should be able to overcome the spread in this one.

View the full market and more odds for Buffalo Bills v San Francisco 49ers on site.

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.