2009 saw UFC 100, the landmark UFC event, held in Mandalay Bay as Brock Lesnar unified the heavyweight title against Frank Mir, with Georges St-Pierre beating Thiago Alves for the welterweight title.
In 2016, we had UFC 200 which featured a litany of star names, with Lesnar making his return to face Mark Hunt, while Daniel Cormier fought Anderson Silva and Amanda Nunes took the women's bantamweight title from Miesha Tate.
UFC 300 promises to be just as mouthwatering, and we run through all you need to know ahead of the historic card.
The UFC's numbered events are usually spaced out around a month apart. UFC 297 is 20th January 2024; UFC 298 is 17th February 2024; UFC 299 is 9th March 2024.
Assuming there are no significant delays, UFC 300 would likely be 6th April 2024, but could well be the week before or after.
A location for UFC 300 has not been confirmed yet, though Las Vegas is the most likely contender and the T-Mobile Arena, which holds 20,000 people, the most fitting venue.
The fight card for UFC 300 has not yet been confirmed, though the likes of Israel Adesanya and Jon Jones are set to miss out.
Jon Jones's injury will keep him out for the first half of 2024, however there are a number of big names who could appear on the card.
If Jones won't be fit until late 2024, Aspinall could be promoted to undisputed champion and face Ciryl Gane. Alternatively, Stipe Miocic could fight Aspinall for the interim title with the winner next in line to fight Jones at the end of the year, though Miocic seems set to wait for Jones.
Islam Makhachev's rematch with Charles Oliveira doesn't yet have a date and makes sense for UFC 300 assuming it isn't schedules any sooner.
Alex Pereira called out Israel Adesanya after his light heavyweight title win over Jiri Prochazka, though Adesanya said he wasn't planning on fighting again for a long time after his defeat to Sean Strickland.
Leon Edwards has eyed up a move to middleweight to fight the winner of Strickland v Du Plessis assuming he beats Colby Covington at UFC 296. But should Edwards lose, a rematch at UFC 300 could be on the cards.
Conor McGregor's coach John Kavanagh recently said that McGregor wasn't set to return until the summer, which would rule him out of UFC 300. When asked on Twitter, however, whether or not he was in or out of UFC 300, McGregor replied with a resounding "In!"
McGregor missed out of UFC 200 having failed to fulfil his media duties in the run-up to the Nate Diaz rematch, announcing his retirement from MMA. Though he quickly reversed his retirement, Dana White remained unmoved, and McGregor headlined UFC 202 instead.
Though White would love McGregor to headline UFC 300, there are stumbling blocks. McGregor only re-entered the USADA testing pool in November, and fighters are required to be in the testing pool for six months which means the earlier the card is, the less likely McGregor is to feature.
Ariel Helwani, however, appearing on the TimboSugaShow, said that he'd heard 'plans were changing' regarding McGregor's inclusion at UFC 300, sparking fresh debate as to whether or not The Notorious would appear at UFC 300.