Following the latest round of results in the Premier League, Everton's Frank Lampard, West Ham's David Moyes and Leicester's Brendan Rodgers are under serious pressure.
The relegation battle is proving to be extremely unpredictable and very tense this campaign, with eight sides currently firmly involved.
Saturday's top-flight action saw six of those teams involved across three games as Southampton, Wolves and Nottingham Forest all earned victories over Everton, West Ham and Leicester respectively.
Leeds' loss to Aston Villa on Friday keeps them firmly in the mix while Bournemouth continue to struggle for results under Gary O'Neil after they went down 2-0 at Brentford, and the Cherries are 1/3 to go down.
The Toffees and Saints are also both odds on to be relegated at 8/11 and 4/5 respectively, with Wolves priced at 9/4, Forest at 12/5 and Leicester at 11/4 while Leeds are available at 16/5 and the Hammers at 4/1.
Everton welcomed rock-bottom Southampton to Merseyside with both clubs desperate for a win, and it was the Toffees who made a positive start.
Amadou Onana opened the scoring late in the first half, before a brace from James Ward-Prowse sealed a 2-1 win for Southampton in the second period.
It's Nathan Jones' first taste of victory in the league since replacing Ralph Hasenhuttl at St Mary's and, although they remain at the foot of the table, Saints have won three in a row across all competitions and momentum appears to be building.
In contrast, Everton haven't won in nine games, losing seven during that sequence, with their last triumph coming when they beat Crystal Palace in the league on 22nd October.
Boss Lampard has been under the spotlight for a while and Saturday's result could potentially be the final nail in the coffin for the former Chelsea manager.
Performing at Goodison has been a major problem for Lampard's side, picking up just eight points across 10 fixtures, losing each of their last four, and they have the second-worst home record in the division.
Everton fans have already made their feelings clear and it appears to be only a matter of time until the board acts to find a replacement for Lampard.
Moyes' second stint in charge of West Ham started well, leading them to a sixth-place finish in his first full campaign before following up with seventh place in 2021/22 and securing European football.
However, the Hammers have struggled to maintain those sort of standards this season and are embroiled in a relegation scrap, even more so after suffering a 1-0 loss to Wolves at Molineux.
Wolves, like Southampton, have already made a change in the dugout with Julen Lopetegui coming in for Bruno Lage and the Spaniard is getting a positive tune out of his players, winning two of his four league outings and losing only once.
There are no signs of improvement at West Ham, though, with Moyes edging closer to the exit following Saturday's result, which leaves his side 18th and one point from safety.
West Ham have failed to win in seven Premier League fixtures, losing six during that run, and the Scot doesn't appear any closer to solving their issues.
The Hammers also have the return of European football to contend with in March, which could provide an unwanted distraction from their domestic exertions, after qualifying for the last-16 of the Conference League.
West Ham and Everton are set to meet next time out in the Premier League and it will be interesting to see if either board has made their move before that clash at 15:00 on 21st January.
The Hammers can be backed at 3/4 in the Full Time Result market, with Everton 7/2 and the draw available at 5/2.
A further defeat against another relegation rival would place the loser in a very precarious position for what remains of the campaign.
Everton won the reverse fixture 1-0 when Neal Maupay scored the only goal at Goodison Park in September but the Hammers prevailed both home and away last term.
There is likely to be a temptation to act from both boards prior to that clash as the January transfer window continues to tick on by.
Any incoming manager would be eager to have some sort of opportunity to reshape his squad to boost his club's hopes of climbing clear of danger.
Of course, changing manager doesn't always have the desired impact but Southampton and Wolves, who have both opted to do that this term, are prime examples of what a fresh boss with new ideas can harness.
Nottingham Forest found it difficult to adapt to life back in the Premier League after a summer of upheaval when they added 22 new players to their squad.
Steve Cooper was seemingly unable to work out his best XI and results suffered as a consequence, with seven defeats in their opening 11 games and just one victory.
The ship appears to have steadied now and they have picked up four wins from the following eight games, including back-to-back victories following Saturday's 2-0 triumph at home to Leicester.
They have subsequently moved ahead of the Foxes and up to 13th with a five-point cushion to the bottom three.
Forest can be backed at 7/4 in the Full Time Result market to win their next match, which takes place on 21st January, against 31/20 Bournemouth and the draw is 9/4.
Leicester, meanwhile, are just two points clear of the drop zone after losing four in a row and Brendan Rodgers, like Lampard and Moyes, is facing a tough road ahead.