Under the stewardship of Jose Mourinho, Inter became the first Italian side ever to win the continental trophy Treble of Serie A, Coppa Italia and the Champions League in 2010.
The Italians finished the job with a stunning 2-0 win over highly-fancied Bayern Munich at the Bernabeu in Madrid, landing the Nerazzurri the biggest prize on offer for the first time in 45 years.
Looking back, it is hardly surprising they conquered all, as Mourinho was blessed with an embarrassment of riches in his squad at San Siro.
Here we take a look at the side who conquered the German giants in that famous final in the Spanish capital and whom the current Inter squad will be looking to emulate against City.
As expected, Bayern threw everything at Inter in the final, but, as you can imagine, they hit stubborn resistance from a typical Mourinho side, well-organised and set-up to frustrate.
The Germans dominated possession (68%) and the shot count (21 to 10), but couldn't make it count, with Cesar proving his worth between the sticks.
The Brazilian cat played more games than anyone for Inter in 2010 and was largely acknowledged to be the best keeper around at the time, with smart saves from Thomas Muller and Arjen Robben in particular, proving crucial.
The rampaging right-back from Brazil scored eight goals in the 2009/10 season, highlighting just how good he was at going forward while also excelling at his defensive duties.
Maicon scored in the semi-final victory over Barcelona and was one of the best in the business on the right flank.
Just don't mention his performance against Gareth Bale in the San Siro when Inter met Tottenham in the Champions League group stage later that year, while he also had a mixed season with Manchester City in 2012/13.
The classy Brazilian was a formidable force in the air and equally adept at striding forward out of defence to launch deadly counter-attacks for Inter.
One of the world's best defenders around, Lucio, played a crucial role after joining for a bargain fee of around £5m and helped stifle numerous Bayern attacks in the Bernabeu.
The uncompromising Argentinian was an intimidating presence for even the best centre-forwards, and many didn't get much change out of the notorious hardman.
His partnership with South American ally Lucio worked to great effect and the pair had a fairly comfortable evening up against Bayern forwards Ivica Olic and Muller.
The classy Romanian was well thought of across Europe as much for his deadly free-kicks as for his defending.
A successful period at Ajax was followed by a spell at Roma, who were forced to sell as debts piled up at the Stadio Olimpico.
Inter snapped him up and the versatile full-back, who could also play at centre-back, played his part in the final despite wearing protective headgear after fracturing his skull earlier in the campaign.
Another Argentinian warhorse, Zanetti, who was just at home at full-back, was Mourinho's midfield general and arguably Inter's greatest-ever servant.
His performances rarely dipped across the course of 858 appearances for the San Siro giants and it was perhaps fitting that he got to lift the ultimate prize for his beloved club, who have since retired his number four shirt.
Completing the Argentinian spine of the team, Cambiasso gets the least acclaim for his part in this all-conquering Inter side, despite being arguably the most crucial component.
His ability to quietly disrupt opposition attacks was second to none, while his work-rate and efficiency went unnoticed to all but perhaps his own team-mates.
After signing on a free from Real Madrid, Cambiasso must rank as one of the greatest pieces of transfer business of all time.
No player provided more assists during the Champions League campaign than midfield maestro Sneijder, who was named UEFA's Club Midfielder of the Year for the 2009/10 season after helping Inter to European glory.
Snapped up after several years at Real Madrid, the Netherlands international was a key man for Mourinho, adding gloss to the grizzled behind him.
Sneijder also grabbed his fair share of goals, scoring in wins over CSKA Moscow and Barcelona in the quarter-finals and semi-finals, respectively, before setting up Diego Milito for the game's opening goal in the final.
No stranger to Champions League glory following his time at Barcelona, Eto'o swapped the Camp Nou for San Siro in an exchange deal with Zlatan Ibrahimovic and the Cameroon striker brought his star quality with him to Italy.
Inter will think they got the better part of the deal as Eto'o bagged 16 goals in all competitions across the 2009/10 season, helping his new side to multiple trophies.
Although outshone by fellow forward Diego Milito in the Champions League final, Eto'o certainly played his part in the treble success.
Until recently, Pandev was still inspiring his nation North Macedonia to famous victories and he played a crucial part in Inter's period of success.
The silky playmaker had a great eye for goal, while providing plenty of opportunities for others.
He couldn't have asked for a better start to his second spell at San Siro where he won the lot after returning in January 2010.
While others did the donkey work, Milito got the glory as his two goals landed Inter the Champions League for the first time in 45 years.
Another of the Argentinian contingent who helped bring huge success to the San Siro, Milito fired in 30 goals for his new club following a prolific spell at Genoa.
Two sublime finishes in the final sealed victory for Inter who now look forward to another shot at the big trophy they have craved since lifting it in their all-conquering 2010 campaign.