There are a total of 29 entries at present for the Commonwealth Cup and North Yorkshire-based handler Kevin Ryan could hold the key to the £600,000 Group 1 sprint, run over the 6f trip at Royal Ascot's five-day festival.
Still a relatively new race to the Flat racing calendar, the first running was in 2015 and was won by the Charles Hills-trained Muhaarar. British trainers have won seven of the nine runnings of the race.
Julie Camacho's Shaquille won last year's renewal of the Commonwealth Cup and went on to be named Europe's Sprinter of the Year at the prestigious Cartier Awards in London. He has been retired to stud.
(Odds will display when market is available)
Trainer Kevin Ryan has confirmed Inisherin will be supplemented for the Commonwealth Cup off the back of his brilliant victory in the Sandy Lane Stakes at Haydock. Once he is supplemented he will probably be shorter than the available 5/1.
Just touched off by subsequent Derby seventh Bellum Justum on debut over a mile at Newmarket in September, the Shamardal colt won at Newcastle on his reappearance before finishing a creditable sixth in the 2,000 Guineas.
Connections decided to drop Inisherin back to 6f at Haydock last month, where he showed a blistering turn of foot to beat some good rivals. He has a high cruising speed and a stiff track like Ascot will play to his strengths.
Vandeek has work to do to reverse the form with Inisherin, as he finished third in the Sandy Lane when losing his unbeaten record at Haydock last month, but the dual Group 1-winning juvenile looked in need of the run on the day.
Simon and Ed Crisford have stated that he has come out of the race very well and they have been very pleased with his work leading into Royal Ascot.
Very testing conditions and having to carry a penalty didn't help Vandeek on his reappearance facing race-fit rivals, but we can expect to see a huge run from last year's Prix Morny and Middle Park winner with the cobwebs blown away on the 5/1 chance.
It's not yet known what River Tiber's intended target is as he also has the option to run in the St James's Palace Stakes over a mile or the Jersey Stakes over 7f, but he is only 6/1 for the Commonwealth Cup and has plenty of speed.
Third behind Rosallion and Haatem in the Irish 2,000 Guineas on his reappearance, that was River Tiber's first crack at a mile and he ran a huge race, so Aidan O'Brien has a bit of a headache now to figure out what race should suit him best.
Dropping back to 6f will be no problem for this horse, who won the Coventry Stakes over track and trip last year. Given the yard has no other standout contender for this race, he might well end up here.
Owner of Inisherin, Sheikh Mohammed Obaid Al Maktoum will more than likely also run Elite Status (7/1). Trained by Karl Burke, the son of Havana Grey was sent off favourite when third in the Norfolk at Royal Ascot last year.
He went on to win a French Group 3 subsequently before falling well short at Group 1 level. Well beaten in the Prix Morny and the Middle Park, he had a lot to prove at this standard.
Elite Status returned from a 231-day absence to land the 6f Listed Carnarvon Stakes at Newbury last month. He might be an improved horse this year, but he will need to be.
Despite having to carry a Group 1 penalty, Bucanero Fuerte (8/1) really impressed after 252 days off the track when toughing out the Group 3 Goffs Lacken Stakes at Naas last month.
Last year's Group 1 Phoenix Stakes winner was very weak in the betting on the day, but got the better of Givemethebeatboys by a head, having to concede 3lb to a fit horse.
Amo Racing's jockey David Egan was still easy on the horse, so huge improvement can be expected.
He has a lot of speed and looks like he will stay further, so the stiff 6f at Ascot should be the ideal test for the Wootton Bassett colt.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.