Defending champion Rafael Nadal may be missing in his pursuit of claiming his 15th French Open title this year, but that may have only made the puzzle in Paris more difficult to solve.
Even without the injured Nadal, Spain may still be optimistic of celebrating success in the second Grand Slam event of the season as they are represented by world number one Carlos Alcaraz, who is 8/5 to follow up his US Open heroics of last season.
But the 20-year-old Murcia man may have to do things the hard way as the top seed is housed in the top half of the draw alongside two-time champion Novak Djokovic as well as 2021 runner-up Stefanos Tsitsipas.
It could, therefore, pay for punters to focus on the bottom half of the draw where , Holger Rune, Jannik Sinner, Casper Ruud and Alexander Zverev will be among those plotting a deep run in the French capital.
It is highly likely that whoever comes through the top half of the draw out of Alcaraz, Djokovic or Tsitsipas will be fancied to be crowned champion.
It would be a huge surprise were one of that trio not to be represented in the title decider, but they will have to work hard for their spot and success in the final would be no guarantee.
The bottom half may lack the quality of the top half but there is still a competitive feel to it with Medvedev, Rune, Sinner, Ruud and Zverev the five standout performers.
Any one of that quintet is capable of taking the title in Paris but second seed Medvedev appears to have hit peak form at the perfect time.
Medvedev has arguably been the form man of the season so far, responding to an underwhelming 2022 campaign with five titles which includes Masters 1000 events in Miami and last time out in Rome.
Clay has always been Medvedev's most vulnerable surface but that recent victory in Rome, which was the first clay-court title of his career, suggested he may have finally adapted to the slower terrain.
Medvedev has made only one quarter-final in six previous trips to the French Open but to claim that title in Rome he had to win six matches and dropped only one set, recording straight-set victories over Zverev, Tsitsipas and Rune.
That is the best recent form on offer and given conditions play similarly in Paris to as they do in Rome, the Russian is expected to make his presence felt from what looks a generous draw.
If able to replicate those performances, Medvedev should have few concerns before a potential quarter-final meeting with Sinner, although the Italian could make only the last-16 of his home event in Rome.
Sinner was forced to withdraw prior to his quarter-final clash in Barcelona at the end of April due to injury, while Medvedev has also shown recently that he can overcome potential semi-final opponents Rune and Zverev on clay.
That makes the second seed look a good each-way bet at .
Medvedev brings the best recent form into the French Open, having won the final preparation event in Rome, and wins over Zverev, Tsitsipas and Rune in Italy suggest he is capable of claiming a second Grand Slam title in Paris.
If Medvedev is to falter in the bottom half of the draw then last year's runner-up Ruud may be in the best position to capitalise.
The Norwegian ace was no match for Nadal in the 2022 final, losing in straight sets, but he had defeated Lorenzo Sonego, Hubert Hurkacz, Rune and Marin Cilic in the build up.
Ruud is considered a clay-court specialist, having won nine of his 10 career titles on the slower surface, and at 24 years of age still has time on his side.
The fourth seed made the semi-final in Rome, where he lost in three sets to Rune, and the Dane is also a potential quarter-final opponent in Paris.
However, Ruud had won the previous four clay-court meetings between the pair and despite them looking evenly-matched, the Norwegian is double the price.
So at , there is every chance this two-time Grand Slam runner-up may have been underestimated and he is another worthy of each-way support.
Ruud found only Nadal too good in last year's French Open but with the legendary Spaniard missing, there is every hope the Norwegian can go one better. The early draw looks kind to Ruud and, if Medvedev underperforms, he may be ready to capitalise.