League One Wycombe won 1-0 at Swansea City in the EFL Cup second round and they face an even tougher challenge against Aston Villa at Adams Park.
Villa climbed to third in the Premier League after Saturday’s 3-1 triumph at home to Wolves.
Tuesday's match between Wycombe and Aston Villa will be available to watch live on Sky Sports Main Event and Sky Sports Football in the UK.
Wycombe v Aston Villa kicks off at 20:00 UK time on Tuesday 24th September and it is being staged at Adams Park in High Wycombe, England.
Wycombe have won five of their last six matches, but they will be up against an equally in-form Aston Villa, who are chasing a fifth straight success.
They have played each other four times, with three victories for Villa and one draw.
Wycombe Wanderers wins | 0 |
Draws | 1 |
Aston Villa wins | 3 |
*H2H stats refer to all competitions
View the latest tips, predictions and odds for Wycombe v Aston Villa
Gideon Kodua, Nathan Bishop, Sam Vokes, Brandon Hanlan and Ryan Tafazolli are expected to remain on the sidelines for the Chairboys.
John McGinn (hamstring) has joined Jaden Philogene (unspecified injury), Matty Cash (thigh), Boubacar Kamara and Tyrone Mings (both knee) on the sidelines.