Barcelona thumped Valencia 7-1 just over a week ago and are unbeaten in 10 meetings with Los Che in all competitions, so the Catalan side should progress to the semi-finals of the Copa del Rey with the minimum of fuss.
La Liga survival is Valencia's main priority this term and the struggling side look to be on the up finally.
Los Che have been languishing in the relegation zone for much of the season, but two wins and a draw from their last four league matches have seen them claw their way off the bottom and just four points from the safety zone.
Barca, of course, are operating at the other end of the table and should maintain their three-way trophy charge with a routine win on Thursday.
Barcelona to win & both teams score - 7/4
Barca are chasing silverware on three fronts this term and they could edge closer to a 32nd Copa del Rey success with a victory over Valencia in this quarter-final clash at the Mestalla on Thursday.
The Catalans are the most successful side in the competition, while they are also chasing La Liga and UEFA Champions League glory in a so-far promising 2024-25 campaign.
Hansi Flick's men have work to do in the league as they are four points behind leaders and bitter rivals Real Madrid, but they made light work of their UEFA Champions League fixtures, finishing second to Liverpool in the 36-team league phase.
But the Copa is held in high regard and they will be confident of making further progress at the hands of struggling Los Che, who they are unbeaten against in 10 meetings.
The last head-to-head went 7-1 in Barca's favour last month, and another commanding victory looks likely, but there is scope to expect a consolation goal for Los Che.
Valencia have scored in 14 of their last 16 meetings with Barca, who have kept just one clean sheet in their last seven outings in all competitions.
Flick could rotate his starting line-up with a hectic schedule forthcoming and that could lead to a disjointed display from the visitors who may present one or two decent goalscoring opportunities to their resurgent hosts.
Valencia have scored in their last nine fixtures and it may be beyond a makeshift Barcelona backline to hold them at bay this week.
Robert Lewandowski first goalscorer - 10/3
Sometimes it is wise not to avoid the obvious and backing Robert Lewandowski to open the scoring in the quarter-final clash should pay off.
The prolific Pole continues to make nets bulge in all competitions and he has plundered 30 goals for his club side this term.
Lewandowski scored the only goal in the 1-0 win over Alaves on Sunday and he has bagged seven goals in his last eight appearances for Barelona.
Taking Barcelona's penalties will aid the cause, but he should have plenty of chances to make his mark from open play also.
Over 6.5 Barcelona shots on target - 11/10
Barcelona are averaging 6.3 shots on target per game in La Liga, but it is a lofty mark of nine in the Copa del Rey this term and the Catalans should be backed to hit the target at least seven times against Valencia on Thursday.
Barbastro and Betis allowed nine each in their meetings with the Blaugrana and Los Che may struggle to stem the tide too.
Barca's last four meetings with Valencia have seen shots on target totals of 11, 6, 13 and 8, so seven looks well within reach at the Mestalla in this cup encounter.
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Valencia - 5/1
Draw - 4/1
Barcelona - 4/9
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.