Uruguay are the joint-record winners of the Copa America with 15 titles and they start their bid for a 16th success when they take on Panama in Group C.
Marcel Bielsa’s men are the third favourites for the crown, behind Argentina and Brazil, and they will be expected to progress out of a group that also contains Bolivia and the United States.
Uruguay v Panama is available to watch live in the UK and will be broadcast on Premier Sports 1.
Uruguay v Panama takes place at the Hard Rock Stadium in Miami, Florida and will kick-off at 02:00 BST.
The two sides have only faced each other on just three previous occasions, with Uruguay coming out on top in each to nil.
The most recent meeting, just over two years ago, saw La Celeste cruise to a 5-0 friendly triumph, with Edinson Cavani (2), Nicolas de la Cruz, Maxi Gomez and Diego Rossi all getting on the scoresheet.
Uruguay wins | 3 |
Draws | 0 |
Panama wins | 0 |
*H2H stats refer to all competitions
Read the latest tips, predictions and odds for Uruguay v Panama.
Marcelo Bielsa has a number of experienced heads to call upon for this Group C clash, most notably Inter Miami striker Luis Suarez - Uruguay’s all-time top goalscorer with 68 - who has 138 appearances for La Celeste.
Panama boss Thomas Christiansen has been dealt a major blow with the news that captain Anibal Godoy will miss the tournament with a thigh injury, so the likes of Abdiel Ayarza and Carlos Harvey could be in line to start in his place.