Manchester City are two wins away from winning a record fourth consecutive Premier League title and will be looking to complete the first assignment by targeting three points against Tottenham in North London.
Spurs are in fifth place after snapping a four-game losing streak with Saturday’s 2-1 victory at home to Burnley.
The Londoners are 11/2 to follow up with another win, but City are the warm 4/11 favourites.
Tuesday's match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League in the UK.
The fixture kicks off at 20:00 BST on Tuesday 14th May and it is being held at the Tottenham Hotspur Stadium.
Manchester City were held to a 3-3 draw by Spurs in last December’s Premier League meeting at the Etihad Stadium and they have been beaten on their last four league visits to Tottenham, failing to score on each occasion.
However, City have won their last seven Premier League games, while Spurs have been beaten in four of their last five league outings.
Tottenham wins | 66 |
Draws | 37 |
Manchester City wins | 67 |
*H2H stats refer to all competitions
Read the latest tips, predictions and odds for Tottenham v Manchester City.
Richarlison, Ben Davies (both calf), Timo Werner (hamstring), Manor Solomon (knee), Destiny Udogie, Ryan Sessegnon (both thigh) and Fraser Forster (ankle) are out of contention.
Jack Grealish (illness) and Nathan Ake (foot) are doubts for the visitors.