Shrewsbury Town will be hoping for an EFL Trophy pick-me-up when Fulham U21 come calling after successive League One defeats to start the season for Paul Hurst's side.
The Craven Cottage youngsters meanwhile are set to have their first competitive outing of the season.
The duo are in Group A of the Southern Section alongside tournament favourites Birmingham City and League Two outfit Walsall.
Shrewsbury Town v Fulham U21 will be broadcast on Sky Sports+ in the UK.
Shrewsbury Town v Fulham U21 has a 19:30 start time on Tuesday 20th August and is being played at The Croud Meadow, Shrewsbury.
Shrewsbury come into this game having lost both matches in League One so far this season, though they did get the better of Notts County in the EFL Cup, winning a penalty shootout after a 3-3 draw at home.
Fulham U21 are set for their first competitive game of the season after their trip to Crystal Palace had to be postponed last week, with Reading U21 awaiting them on Saturday in their Premier League 2 opener.
Fulham U21 visited Portugal and Canada as part of their pre-season preparations, playing three games against Cavalry U21s, Vancouver U23s and League1 BC Selects in North America.
These two sides have not met before.
Shrewsbury Town wins | 0 |
Draws | 0 |
Fulham U21 wins | 0 |
Captain Carl Winchester scored his first goal for the club on Saturday in the 4-1 loss against Peterborough United.
The back four was Luca Hoole, Toto Nsiala, Morgan Feeney and Mal Benning for that reverse, while Winchester sat in the holding role behind Harrison Biggins and Jordan Shipley. Tom Bloxham and Tommi O'Reilly supported John Marquis as the central striker.
Manager Hurst may opt for some changes in this EFL Trophy opener.
Hayden Mullins' side were due to face Crystal Palace in their Premier League 2 opener on Friday evening but the game was called off.
The likes of Terrell Work, Tom Olyott and Aaron Loupalo-Bi have been in goalscoring form in pre-season for the Whites.