Shane McWilliams scored the only goal when Rotherham United beat Bradford City in Group H of the EFL Trophy and the Millers will look to back that up when the pair meet in the quarter-finals on Tuesday.
McWilliams will miss this game at the New York Stadium with a hamstring issue, but City have received a far more significant blow in recent weeks with the news that star striker Andy Cook's season is over because of a serious knee injury.
Cook's absence looks a real issue for Graham Alexander, with the scoring focus falling on youngster Calum Kavanagh and, while the Millers may also be missing Jonson Clarke-Harris, they still have several options to select from.
Among them is Sam Nombe and he is tipped to play a leading role in firing Tuesday's hosts into the last four and a game away from Wembley.
Rotherham to win - 21/20
McWilliams' fifth-minute effort on 19th November proved enough in the Group H meeting and a similar outcome could be the case on Tuesday.
The Millers, two-time winners of this competition, have had a mixed season and sit 15th in League One after losing 2-1 at leaders Birmingham City on Saturday.
That was their second defeat in three games, but both of those losses have come on the road and they are unbeaten in four at home, drawing with Stockport County before beating Bolton Wanderers, Charlton Athletic and Cambridge United.
With them seven points outside of the play-offs, Steve Evans' side could still make the top six, but if not, winning this tournament could save their campaign.
A penalty shootout win at Chesterfield got them to this point and they will be confident against last season's beaten semi-finalists Bradford, whose eight-game unbeaten run was ended by Saturday's 1-0 defeat at AFC Wimbledon.
The League Two outfit beat Aston Villa's youngsters 3-1 in the round of 16, but have a poor road record, winning only three of their 14 League Two matches on the road compared to 10 victories in 14 at home.
Rotherham can make the most of home advantage and book their place in the semi-finals.
Sam Nombe anytime goalscorer - 9/4
Nombe scored the Millers' goal at Birmingham on Saturday and, although his club has a list of familiar names who can fill their frontline, he will hope to keep his place for Tuesday's match.
Before getting the nod at St Andrew's, the former Exeter City forward had started on the bench for his team's last three, but he is a player who thrives when given a run of games.
A first EFL Trophy goal of the season would be timely and he has experienced netting against the Bantams, scoring for the Grecians in a 1-1 FA Cup first round draw in 2021/22.
Team-mate Jordan Hugill has scored three times in this competition, but has failed to find the net since October.
Nombe has the nous to get in behind a defence that has only conceded more than one goal once in the last nine in all competitions.
Home team highest-scoring half - 2nd half - 11/8
While Rotherham have attacking options, City's season so far has been built on a strong defence and the earlier fixture between these two could be instructive.
A victory on Tuesday will take the victor within a game of Wembley and it could be another tight match between these Yorkshire rivals.
More goals have been scored in the second half of Rotherham's last two fixtures and could land again here, while optimistic punters might take the 9/2 for Draw/Rotherham in the half-time/full-time prices.
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Rotherham United - 21/20
Draw - 9/4
Bradford City - 21/10
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.