After comfortably qualifying for next summer's Euros, England will hope to finish their Group C qualifying campaign on a high when they take on North Macedonia.
The Three Lions are already assured of top spot and a draw on Monday will be enough to guarantee them a top seeding for Germany but they will want to put on a better show than they managed in Friday's lacklustre 2-0 home win over Malta.
North Macedonia are destined to finish fourth in the group and cannot qualify as they have picked up just two wins and one draw so far and the reverse fixture ended 7-0 to England at Old Trafford in June.
England should finish their group campaign with a comfortable win but, with little riding on the result, the hosts can play their part too.
When the Three Lions triumphed 7-0 at home earlier in the campaign the group was yet to be settled but, with this being a dead rubber now they have sealed top spot, Southgate's side are unlikely to be at their best.
This could therefore follow a similar pattern to Friday's game, when England laboured to a 2-0 win over Malta and the home side should get opportunities on the night, with Southgate expected to make more changes and give several fringe players the chance to impress.
England just about kept a clean sheet against Malta, but the visitors were somewhat unfortunate not to score and North Macedonia, who have scored nine goals in their qualification campaign, are a better side.
That is evidenced by the fact they have beaten Malta home and away, while they also drew 1-1 at home to Italy earlier in the group.
North Macedonia have only failed to score in two of their qualifiers - that Wembley clash and a 2-0 defeat to Ukraine in Prague - while they have got on the scoresheet in all of their home games so far.
And there is a good chance of them maintaining that record on Monday.
The last time England failed to score was in the 0-0 group stage game against USA in last winter's World Cup and they have hit 21 from their first seven games in qualifying, so they will expect to bag at least a couple more in Skopje.
With Marcus Rashford limping off against Malta, Southgate could turn to Man City winger Jack Grealish to start down the left after he remained on the bench at Wembley.
The Three Lions boss is expected to make full use of his squad in Skopje and the players who didn't get on the pitch in the 2-0 win will expect to get a chance in the final qualifying game, with one of them being Grealish.
The former Aston Villa man has scored just two goals so far for his country, but will view this game as an ideal occasion to improve that record and, with England not playing again until March, he will be keen to impress Southgate ahead of next summer's tournament.
Kane's start to life with Bayern Munich could hardly have gone any better this season with the frontman scoring 21 goals for the German giants in his first 16 appearances.
He continued his fine form on the international stage when scored the second goal on Friday, his 62nd for his country, and he will surely get more opportunities to add to that tally against North Macedonia.
Kane scored two in the 7-0 home win over Monday's opponents and there's an argument to suggest he's in the form of his life at the moment in front of goal, underlined by the fact he's had 14 shots on target in his last five appearances for his club.
The 30-year-old is never short of confidence and is always prepared to try his luck when he gets a sight of goal so backing him at to have at least two shots on target against North Macedonia appeals.
Jani Atanasov came off the bench to score twice against Italy on Friday, so the Cracovia man will hope to earn a place in the starting line-up.
The likes of Napoli's Elif Elmas, Trabzonspor's Enis Bardhi and Ezgjan Alioski - who plays for Al-Alhi - should all also be in Blagoja Milevski's side from the start.
Rashford is set to be ruled out after being forced off against Malta, while Nick Pope, John Stones, Luke Shaw, Reece James, Jude Bellingham and James Maddison are among the list of players unavailable.
The England boss will make changes again and there could be a first cap at left-back for Rico Lewis, while Bukayo Saka, Kalvin Phillips, Kyle Walker, Declan Rice and Grealish could also come in for starts.
England have only dropped two points in their qualifying campaign, the 1-1 draw with Ukraine in September and hammered North Macedonia 7-0 at home.
North Macedonia's two wins in the group both came against Malta, while they also held European champions Italy to a 1-1 draw at home earlier in qualifying.
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.