The UEFA Europa League has also undergone a makeover ahead of the new season and Midtjylland and Hoffenheim face each other as the new-look 36-team league phase begins.
Bundesliga outfit Hoffenheim are back in European competition after a couple of years away, while Danish champions Midtjylland were eliminated from the UEFA Champions League qualifiers earlier this season.
How to watch Midtjylland v Hoffenheim and TV channel
The game between Midtjylland and Hoffenheim will be broadcast on Discovery+ in the UK.
Midtjylland v Hoffenheim kick-off time, date and venue
The Europa League clash between Midtjylland and Hoffenheim kicks off at 20:00 on Wednesday 25th September and will be played at the Arena Herning in Herning, Denmark.
Midtjylland v Hoffenheim stats and head-to-head record (H2H)
Danish champions Midtjylland were knocked out of the UEFA Champions League qualifiers by Slovan Bratislava, ensuring that they dropped into this competition.
They have lost just one of their last nine Europa League home games.
Midtjylland are sitting top of the Danish Superliga after nine games, but were held 2-2 by Randers at the weekend, though Aral Simsir's late penalty earned them a point after they had been reduced to 10 men.
Pellegrino Matarazzo's Hoffenheim finished seventh in the Bundesliga last season to provide them a route into Europe.
They won their league opener against 10-man Holstein Kiel in August but have lost all three games since. There have been at least three goals in six of Hoffenheim's last seven competitive matches.
These two sides have not met in a competitive game before.
Midtjylland v Hoffenheim team news
Midtjylland team news
Boss Thomas Thomasberg looks set to be without forwards Gue-Sung Cho and Marrony, as well as midfielder Kristoffer Olsson and defender Paulinho
Hoffenheim team news
The Bundesliga side count Ihlas Bebou, Finn Becker, Ozan Kabak, Christopher Lenz and Grischa Promel amongst their list of absentees, while Florian Grillitsch and David Jurasek are doubts.
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