Outclassing the reigning champions on their own patch, however out of sorts they might be, is a statement and Liverpool moved 11 points clear at the top of the Premier League with Sunday's 2-0 win over Manchester City.
They could be forgiven for taking their eye off the ball. However, as they are still involved in the UEFA Champions League, Arne Slot's side need to maintain their momentum, especially with a free weekend coming up following their early elimination from the FA Cup.
Liverpool could also win the EFL Cup on 16th March and have a chance to land a psychological blow against their Wembley opponents when Newcastle travel to Merseyside.
Traditionally among the Premier League's most entertaining fixtures, the duo played out a barnstorming 3-3 draw in December and an equally entertaining clash could be on the cards on Wednesday.
Liverpool to win and over 3.5 goals - 15/8
Liverpool are unbeaten in their last 28 home games against Newcastle, a run stretching back to 1994 and the Magpies have a miserable record against the Reds, having failed to win any of their last 16 meetings.
However, records are there to be broken and having won at Arsenal in the EFL Cup and Tottenham and Manchester United in the league, Eddie Howe's side clearly enjoy playing on the road.
They were also unlucky against Liverpool earlier in the season and can pose a real threat.
Howe's men beat Nottingham Forest 4-3 on Saturday, their third game on the spin in all competitions to feature four or more goals.
Considering how open the reverse match was and that Liverpool won last season's edition of this clash 4-2, exactly six goals might be worth chancing at a handsome 10/1.
It promises to be a fascinating contest but Liverpool's performance against City suggests that they have emerged from a mini-wobble and can add another three points to their tally.
Mohamed Salah anytime goalscorer - 20/21
It may not be the most insightful move to back an odds-on shot but Mohamed Salah's form is such that he is worth getting behind at whatever price is available.
The Egyptian provided a goal and an assist at the Etihad and another strike at Anfield will see him net 10+ home goals and 10+ away goals in three different Premier League campaigns.
Harry Kane is the only player to have previously achieved that feat, doing it five times while at Tottenham and in his current form and with him out of contract in the summer, Reds fans will be hoping Salah sticks around for another couple of seasons to try and match the England skipper.
Salah has previously netted 10 Premier League goals against Newcastle, including twice at St James' Park in December when he rescued Liverpool on a rare off evening.
The 32-year-old is arguably the form player on the planet and is worth backing to score for an incredible ninth game in a row in all competitions.
Alexander Isak anytime goalscorer - 9/4
Newcastle are hardly without a threat, though, with Alexander Isak among the form forwards in the Premier League.
The Swede has scored 10 away goals in the league this season and needs one more to match Alan Shearer's 11 in 2001/02 and another couple of strikes to draw level with Andy Cole's Newcastle record of 12 in 1993/94.
Isak's brace in the win over Forest took his league tally to 19 and he also scored the opener in the reverse fixture, as well as being on target in Newcastle's last two trips to Anfield.
The 25-year-old has been linked with a move away from Tyneside but the freedom he plays with under Howe and the possibility of European football next season means he may well stay put.
His brace against Forest ended a rare four-game dry patch for the Solna-born star. He tends to score in batches and could make his mark again on Merseyside.
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Liverpool - 1/2
Draw - 7/2
Newcastle - 19/4
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.