Crystal Palace are surging up the table and could prove awkward opponents for a Manchester United side lacking confidence.
The Red Devils remain in the European hunt, but while the Eagles are playing with real clarity under Oliver Glasner, the uncertainty over United counterpart Erik ten Hag's future is manifesting itself in muddled performances, most recently drawing 1-1 at home to Burnley.
The game will be shown on Sky Sports Main Event and Premier League.
Crystal Palace v Manchester United will kick off at 20:00 on Monday 6th May at Selhurst Park, London.
United have dominated this rivalry over the years, winning 41 of the pair's 65 meetings. However, they lost September's reverse game 1-0, with Joachim Andersen scoring the only goal.
A win for Palace on Monday will see them complete the league double over United for the first time ever, although the Red Devils have beaten their opponents this season, triumphing 3-0 in the EFL Cup.
Arguably the pair's most famous meeting was the 1990 FA Cup final, drawing the original tie 3-3 before Lee Martin netted the Red Devils' winner in the replay, a 1-0 victory.
Crystal Palace wins | 11 |
Draws | 13 |
Manchester United wins | 41 |
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Glasner has confirmed that Marc Guehi will return to the matchday squad for the first time since February after recovering from a knee injury, while Eberi Eze is also due back after the Austrian opted not to risk aggravating his knee issue in last Saturday's 1-1 draw at Fulham.
Captain Bruno Fernades is a doubt with an unspecified injury. Marcus Rashford is also absent, while Scott McTominay will be assessed but Jonny Evans should be available.