A total of 16 teams from across the Americas will battle it out to be crowned Copa America champions and a host of Premier League talent will be on show during the proceedings in the United States.
As the tournament start date draws ever closer on the 20th June, we take a look at who will be searching for continental glory from the Premier League for each of the competing nations.
Argentina
Reigning Copa America and World champions Argentina have no less than 10 Premier League representatives in their preliminary squad, with the vast majority expected to be named in the final squad come the end of the pre-tournament warm-up matches against Ecuador and Guatemala.
Aston Villa goalkeeper Emiliano Martinez has asserted himself as Lionel Scaloni’s No. 1 and will likely start between the sticks for the holders, while fellow World Cup winners Lisandro Martinez (Manchester United), Cristian Romero (Tottenham Hotspur), Gonazalo Montiel (Nottingham Forest), Alexis Mac Allister (Liverpool), Enzo Fernandez (Chelsea) and Julian Alvarez (Manchester City) will all be expected to feature in some capacity over the tournament.
The remaining members of the squad from England’s top tier sees Brighton’s Valentin Barco, Tottenham’s Giovani Lo Celso and Manchester United’s Alejandro Garnacho all vying for spots in Lionel Scaloni’s squad.
Peru
No members of Jorge Fossati’s provisional 44-man squad currently play in the Premier League, although striker Andre Castillo did spend a season on loan at Watford in the 2017/18 season, scoring one top flight goal.
Chile
Goalkeeper Lawrence Vigouroux and striker Ben Brereton Diaz were members of Premier League squads last season, although neither will play in the top flight next season after suffering relegation with Burnley and Sheffield United respectively.
The 55-man provisional squad named by Ricardo Gareca also includes a host of former Premier League stars in the form of Claudio Bravo (Manchester City), Gary Medel (Cardiff City), Mauricio Isla (QPR), Francisco Sierralta (Watford), Alexis Sanchez (Arsenal, Manchester United) and Eduardo Vargas (QPR).
Canada
Tom McGill is the third choice goalkeeper at Brighton and young defender Luc de Fougerolles is on the books at Fulham, while the Canucks are managed by former Leeds boss Jesse Marsch.
Their forward line includes former Blackburn, QPR and Cardiff winger Junior Hoilett as well as Liam Millar, currently of Championship side Preston, who featured in one FA Cup match for Liverpool back in 2020.
Mexico
There is just one current Premier League player in Jaime Lozano’s Mexico squad in the form of West Ham holding midfielder Edson Alvarez, however both Uriel Antuna and Marcelo Flores had brief spells at Manchester City and Arsenal respectively in their early careers, although neither made an appearance for the first team in any capacity.
Ecuador
Chelsea star Moises Caicedo will likely be the focal point of the Ecuadorian midfield while Jeremy Sarmiento, who was on loan at Ipswich Town from Brighton last season, has 15 appearances for his national side and could feature.
Talismanic striker Enner Valencia also spent time in the Premier League with West Ham and Everton, netting eight goals over three years in England.
Venezuela
There are no current Premier League players representing Venezuela at the Copa America, however La Vinotinto will likely start former West Brom, Newcastle and Everton striker Salomon Rondon up front, with the 34-year old leading the way in terms of goals for his country on 41.
Jamaica
Fulham midfielder Bobby Decordova-Reid and West Ham striker Michail Antonio will both represent the Reggae Boyz in June, while Michael Hector (Fulham), Dexter Lembikisa (Wolves) and Kasey Palmer (Coventry) have all made a handful of appearances in the Premier League.
United States
Gregg Berhalter has a wide array of current and former Premier League talent in his training squad for the Copa America.
Goalkeeper Matt Turner (Nottingham Forest), defenders Tim Ream, Antonee Robinson (both Fulham), Chris Richards (Crystal Palace) and midfielders Giovanni Reyna (Nottingham Forest) and Tyler Adams (Bournemouth) all currently ply their trade in England’s top flight.
Other members of the Yanks’ squad to have featured in the Premier League are Weston McKennie, Brenden Aaronson (both Leeds), Christian Pulisic (Chelsea), Josh Sargent (Norwich) and Folarin Balogun (Arsenal).
Uruguay
Uruguay are now managed by former Leeds boss Marcelo Bielsa and he has a handful of current Premier League stars to call upon in the form of Wolves defender Santiago Bueno - although he was not named in the recent friendly squad to face Mexico - Tottenham midfielder Rodrigo Bentancur and Liverpool striker Darwin Nunez.
Panama
No members of Thomas Christansen’s provisional Panama squad have or currently play in the Premier League.
Bolivia
No members of Zago’s provisional Bolivia squad have or currently play in the Premier League.
Brazil
Eight members of Dorival Junior’s confirmed 26-man squad play in England’s top flight in the form of goalkeeper Alisson (Liverpool), defender Gabriel Magalhaes (Arsenal), midfielders Bruno Guimaraes (Newcastle), Douglas Luiz (Aston Villa), Lucas Paqueta (West Ham), Joao Gomes (Wolves), Andreas Pereira (Fulham) and winger Gabriel Martinelli (Arsenal).
Danilo and Raphinha have also spent time in the Premier League in previous seasons with spells at Manchester City and Leeds respectively.
Colombia
Nestor Lorenzo’s squad includes the likes of Daniel Munoz, Jefferson Lerma (both Crystal Palace), Luis Sinisterra (Bournemouth), Jhon Duran (Aston Villa) and Luis Diaz (Liverpool).
There are also plenty of former Premier League stars among the Colombian side, most notably former Arsenal shot-stopper David Ospina, former Everton centre-back Yerry Mina and former Toffees attacking midfielder James Rodriguez.
Paraguay
Newcastle winger Miguel Almiron and Brighton’s Julio Enciso are both set to represent Los Guaranies at the Copa America, while former West Ham centre-back Fabian Balbuena has also been named in Daniel Garnero’s provisional squad.
Costa Rica
Nottingham Forest midfielder Brandon Aguilera is the only current Premier League player representing Gustavo Alfaro’s Costa Rica side, while former Arsenal forward Joel Campbell will likely lead the line for Los Ticos in the US.