Colo-Colo host River Plate in the first leg of their Copa Libertadores quarter-final, with the bottom seeds looking to make full use of home advantage.
The Chileans scraped through the group stage with just six points, while River took 16 points from a possible 18, and the four-time champions will expect to progress over the two legs.
Colo-Colo v River Plate in the Copa Libertadores is available to watch live on bet365's Live Streaming Service.
Colo-Colo v River Plate is scheduled for a 23:00 (BST) kick-off on Wednesday 18th September at Estadio Monumental David Arellano, in Santiago, Chile.
Colo-Colo have won their last seven games at home.
River Plate are unbeaten in their last eight games.
River Plate have won their last four competitive games with Colo-Colo by a combined score of 9-2.
Colo-Colo wins | 0 |
Draws | 1 |
River Plate wins | 5 |
*H2H stats refer to last six meetings and includes friendlies