Chelsea host Swiss outfit Servette at Stamford Bridge as Enzo Maresca's Blues look to take their place in the UEFA Conference League group phase for this season.
The Premier League outfit will be expected to see off the visitors over two legs but, with major personnel changes at Chelsea once more this summer, they'll be taking nothing for granted.
Maresca may view this third tier European competition as a great chance to secure silverware this season.
Chelsea v Servette will be televised live on TNT Sports in the UK.
Chelsea vs Servette is scheduled for a 20:00 BST kick-off on Thursday 22nd August, with the first leg taking place at Stamford Bridge.
This will be the first meeting between these clubs. Servette were edged out by Braga in the Europa League qualifiers before dropping into this competition, having finished third in Switzerland's top flight last season while winning the Swiss Cup.
The Blues have made major changes again over the summer as Maresca replaced Mauricio Pochettino in the dugout.
Read the latest tips, predictions and odds for Chelsea v Servette.
Reece James could miss out due to a hamstring injury, though Filip Jorgensen, Pedro Neto and Kiernan Dewsbury-Hall could be included from the start if Maresca opts for changes after Sunday's Premier League defeat at home to Manchester City.
Raheem Sterling has been left out of the squad once more.
Julian von Moos is fresh from a cup hat-trick against minnows Signal FC Bernex last time out, while Swiss international Dereck Kutesa is another attacking threat.
Former France youth international Enzo Crivelli provides a physical option up top.